Name: Miss Luksamee Worasuttayangkurn Office address: Laboratory of Pharmacology, 4thFloor, Biomedical Science Building 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2553 8555 (ext. 3162) E-mail: Position: Research Scientist I Research Interests • Toxicity testings Education Mahidol University, M.Sc. in Toxicology Chulalongkorn University, B.Sc. in Botany Area of expertise • Animal toxicity testing Publications •Sodium arsenite exposure impairs B cell proliferation and enhances vascular inflammation in Plasmodium berghei mouse model Suntararuks S,Worasuttayangkurn L, Akanimanee J, Suriyo T, Nookabkaew S, ,Srisamut N, Visitnonthachai D, Watcharasit P, Satayavivad J. Environ Toxicol Pharm. 2019; 66: 7-13. •Safety evaluation of longan seed extract: Acute and repeated oral administration. Worasuttayangkurn L, Watcharasit P, Rangkadilok N, Suntararuks S, Khamkong P, Satayavivad J Food Chem Toxicol 2012; 50: 3949-55. •Immunomodulatory effects of cadmium andGynostemma pentaphyllumherbal tea on rat splenocyte proliferation. Suntararuks S, Yoopan N, Rangkadilok N,Worasuttayangkurn L, Nookabkaew S, Satayavivad J. J Agric Food Chem. 2008; 56:9305-11. •Evaluation of free radical scavenging and antityrosinase activities of standardized longan fruit extract. Rangkadilok N, Sitthimonchai S,Worasuttayangkurn L, Mahidol C, Ruchirawat M, Satayavivad J. Food Chem Toxicol. 2007; 45:328-36. •Inhibitory effect ofAndrographis paniculataextract and its active diterpenoids on platelet aggregation. Thisoda P, Rangkadilok N, Pholpana N,Worasuttayangkurn L, Ruchirawat S, Satayavivad J. Eur J Pharmacol. 2006; 553:39-45. •Identification and quantification of polyphenolic compounds in Longan...

Name: Mrs. Nanthanit Pholphana Office address: Laboratory of Pharmacology, 4thFloor, Biomedical Science Building 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2553 8555 (ext. 3164) E-mail: Position: Research Scientist I Research Interests • Bioactive compounds in medicinal plants and foods • Pesticide residues in biological and environmental samples • Pharmacokinetic studies of medicinal plants • Oxidative stress biomarker Education • Master of Science (Microbiology), Faculty of Science, Mahidol University • Bachelor of Science (Health Science, first class honors), Faculty of Science and Technology, Thammasart University Area of expertise • Analytical chemistry (LC-MS/MS, HPLC, Supercritical Fluid Extraction) Publications •Clinical parameters following multiple oral dose administration of a standardizedAndrographis paniculata</> capsule in healthy Thai subjects. Suriyo T,Pholphana N, Ungtrakul T, Rangkadilok N, Panomvana D, Thiantanawat A, Pongpun W, Satayavivad J. Planta Med. 2017;83: 778–789. •Andrographis paniculata: dissolution investigation and pharmacokinetic studies of four major active diterpeniods after multiple oral dose. Pholphana N, Panomvana D, Rangkadilok N, Suriyo T, Puranajoti P, Ungtrakul T, Pongpun W, Thaeopattha S, Songvut P, Satayavivad J. J Ethnopharmacol 194 p513-21 (2016) •A simple and sensitive LC-MS/MS method for determination of four major active diterpenoids fromAndrographis paniculatain human plasma and its application to a pilot study. Pholphana N, Panomvana D, Rangkadilok N, Suriyo T, Ungtrakul T, Pongpun W, Thaeopattha S, Satayavivad J. Planta...

Name: Miss Daranee Visitnonthachai Office address: Laboratory of Pharmacology, 4thFloor, Biomedical Science Building 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2553 8555 E-mail: Position: Research Scientist I Research Interests • Molecular and Cell signalings Education • M.Sc. Biochemistry, Kasetsart University Area of expertise • Protein analysis, Flow cytometry Publications •Sodium arsenite exposure impairs B cell proliferation and enhances vascular inflammation in Plasmodium berghei mouse model Suntararuks S, Worasuttayangkurn L, Akanimanee J, Suriyo T, Nookabkaew S, ,Srisamut N,Visitnonthachai D, Watcharasit P, Satayavivad J. Environ Toxicol Pharm. 2019; 66: 7-13. • Arsenic impairs insulin signaling in differentiated neuroblastoma SH-SY5Y cells. Niyomchan A,Visitnonthachai D, Suntararuks S, Ngamsiri P, Watcharasit P, Satayavivad J. NeuroToxicology 2018;66: 22-31. • Paraquat induces extrinsic pathway of apoptosis in A549 cells by induction of DR5 and repression of anti-apoptotic proteins, DDX3 and GSK3 expression. Hathaichoti S,Visitnonthachai D, Ngamsiri P, Niyomchan A, Tsogtbayar O, Wisessaowapak C, Watcharasit P, Satayavivad J. Toxicol in Vitro. 2017;42: 123-129 • Sodium arsenite inhibited genomic estrogen signaling but induced pERα(ser118) via MAPK pathway in breast cancer cells. Nakareangrit W, Thiantanawat A,Visitnonthachai D, Watcharasit P, Satayavivad J. Environ Tox. 31 p1133-46 (2016) • Chlorpyrifos promotes colorectal adenocarcinoma H508 cell growth through the activation of EGFR/ERK1/2 signaling pathway but not cholinergic pathway. Suriyo T, Tachachartvanich P,Visitnonthachai D, Watcharasit P, Satayavivad...

Name: Dr. Tawit Suriyo Office address: Laboratory of Pharmacology, 4th Floor, Biomedical Science Building 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2553 8555 (ext. 3159) E-mail: Position: Research Scientist Research Interests • Metals (i.e. mercury, cadmium, arsenic) and pesticides (i.e. paraquat, glyphosate, chlopyrifos) toxicity including immunotoxicity, cardiovascular toxicity, and carcinogenicity • Pharmacology and toxicology of natural products • Neuronal and non-neuronal cholinergic system Education 2009-2010 Post-doctoral Fellow, Center of Excellence on Environmental Health and Toxicology, Commission of Higher Education, Ministry of Education, Thailand 2003-2008 Ph.D. (Environmental Engineering and Management; Environmental Toxicology, Technology and Management), Inter-university program between Asian Institute of Technology (AIT)/ Chulabhorn Research Institute (CRI) and Mahidol University (MU), Thailand 1999-2001 M.Sc. (Toxicology), Mahidol University, Thailand 1995-1998 B.Sc. (Industrial Hygiene and Safety), Burapha University, Thailand Area of expertise •In vitroandin vivostudies • Cell cycle and cell signaling • Flow cytometry-based assay • Gene expression assay • Intracellular calcium assay Award 2015 SOT/AstraZeneca/SOT Endowment Fund / IUTOX Travel Award, International Union of Toxicology (IUTOX) and US Society of Toxicology (SOT), San Diago, USA. “Suriyo T, Tachachartvanich P, Watcharasit, Satayavivad J. Chlorpyrifos promotes the growth of colorectal adenocarcinoma H508 cells through the activation of EGFR/ERK1/2 signaling pathway” ImmunoTools Special Award, ImmunoTools GmbH Company, Germany. “Suriyo T. The immune stimulation and anti-inflammation properties of Thai...

Name: Dr. Piyajit Watcharasit Office address: Laboratory of Pharmacology, 4thFloor, Biomedical Science Building 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2553 8555 (ext. 3150) E-mail: Position: Research Scientist II Research Interests Neurodegenerative diseases, cell signalings Education Ph.D. (Pharmacology) University of Alabama at Birmingham, Birmingham, Alabama, USA Awards Ph.D. Thesis award (Honorably mentioned) 2003 from National Research Council of Thailand Publications • Sodium arsenite exposure impairs B cell proliferation and enhances vascular inflammation in Plasmodium berghei mouse model Suntararuks S, Worasuttayangkurn L, Akanimanee J, Suriyo T, Nookabkaew S, ,Srisamut N, Visitnonthachai D,Watcharasit P, Satayavivad J. Environ Toxicol Pharm. 2019; 66: 7-13.•Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors Tanjak P, Thiantanawat A,Watcharasit P, Satayavivad J. Int J Oncol. 2018; 53(1): 177-188.• Arsenic impairs insulin signaling in differentiated neuroblastoma SH-SY5Y cells. Niyomchan A, Visitnonthachai D, Suntararuks S, Ngamsiri P,Watcharasit P, Satayavivad J. NeuroToxicology 2018;66: 22-31.• Paraquat induces extrinsic pathway of apoptosis in A549 cells by induction of DR5 and repression of anti-apoptotic proteins, DDX3 and GSK3 expression. Hathaichoti S, Visitnonthachai D, Ngamsiri P, Niyomchan A, Tsogtbayar O, Wisessaowapak C,Watcharasit P, Satayavivad J. Toxicol in Vitro. 2017;42: 123-129• Perfluorinated chemicals, PFOS and PFOA, enhance the estrogenic effects of 17 β –estradiol in T47D...

Name: Dr. Nuchanart Rangkadilok Office address: Laboratory of Pharmacology, 4thFloor, Biomedical Science Building 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2553 8555 (ext. 3157) E-mail:   Position: Research Scientist I Research Interests • Plant physiology, Phytochemical analysis, Pharmaceutics and standardization of Thai traditional medicines • Pharmacokinetic of phytochemical compounds in human, Metal analysis in food and its biotransformation Education 1999-2002 Ph.D. (School of Agriculture and Food Systems) The Melbourne School of Land and Environment The University of Melbourne, Australia 1989-1993 Bachelor of Pharmacy (second class honors) Faculty of Pharmacy Chiang Mai University, Chiang Mai, Thailand Area of expertise • Extraction and isolation of phytochemical compounds from medicinal plants • Liquid-liquid and solid phase extraction • TLC, HPLC/GC analysis of phytochemical compounds Publications – Arsenic speciation and accumulation in selected organs after oral administration of rice extracts in Wistar rats. Lewchalermvong K,Rangkadilok N, Nookabkaew S, Suriyo T, Satayavivad J. J Agric Food Chem. 2018, 66: 3199-3209. – The role of nutrition in influencing mechanisms involved in environmentally mediated diseases. Hennig B, Petriello MC, Gamble MV, Surh Y-J, Kresty LA, Frank N,Rangkadilok N, Ruchirawat M, Suk WA. Rev Environ Health. 2018; 33: 87-97 – Clinical parameters following multiple oral dose administration of a standardizedAndrographis paniculatacapsule in healthy Thai subjects. Suriyo T, Pholphana N, Ungtrakul T,Rangkadilok...

Name: Jarunee Thuraphan Office address: Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2553 8555 (ext. 3129) (office) Fax:+662–553–8572 Position: Research Assistant, Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute E–mail: [email protected] Education and Degree B.Sc. (Biology), Ramkhamhaeng University, 1998–2004 Work Activities Marketing, General drug house Ltd., 2003–2005 Research Assistant, Research Ethic Committee, Academic Support Department, Rajavithi Hospital, 2005–2010 Research Assistant, Chemical Carcinogenesis laboratory, Chulabhorn Research Institute, 2011–present

Name:Ms. Donlaporn Sriphan Office address: Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662–5538555 (ext. 3133) Fax:– Positions:Research Scientist, Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute E–mail:[email protected] Website:– Research Interests Microbiome Bioinformatics Cancer Education and Degrees: Thammasat University, 2009 – 2016, Chulalongkorn University, 2013 – 2016 B.Sc. (Biotechnology), Thammasat University, TH., 2012 M.Sc. (Microbiology and microbial technology), Chulalongkorn University, TH. 2016 ORCID iD: https://orcid.org/0000-0003-2883-3357 Publications Sripan, D., Wilantho, A., Khitmoh, K., Wongsawaeng, D., Ouazzani, J., Chavanich, S., Tongsima, S., Somboonna, N. (2021). Marine Bacteria Community in a 150–m Depth Tachai Island, the Southeast Andaman Sea of Thailand. Frontiers in Marine Science, 8. doi:10.3389/fmars.2021.624624  

Name: Miss Buasai Akachart Office address: Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2553- 8555 (ext. 3146) Fax:+662–553–8572 E-mail: [email protected] Position: Research Assistant, Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute Education and Degrees: B.Sc. (Biotechnology), Khon kaen University, 2003-2007 Work Activities Research Assistant, Department of Biotechnology, Faculty of Technology Khon kaen University, 2008-2011 Research Assistant, Chemical Carcinogenesis Laboratory, Chulabhorn Research Institute. Responsible for biobank data depository and initial data quality control steps, 2012-present Publications Yuvadetkun, P., Ackachat, B., & Boonmee, M. (2017). Repetitive dilute acid hydrolysis of sugarcane bagasse for ethanol production by Candida shehatae TISTR 5843. Asia-Pacific Journal of Science and Technology, 18(1), 112-121. Retrieved from https://so01.tci-thaijo.org/index.php/APST/article/view/82820  

Previous Next        Our laboratory has emphasized on the importance of research utilization in the areas of polymer sciences for medical devices and standardized preparation of Kratom extracts as well as essential oils, with an ultimate aim for their applications in the industry. Standardized herbal extracts and essential oils such as those from mangosteen peels, galanga, betel vine, white turmeric, and white ginger have been developed on a lab/pre-pilot scale.        Double-layered wound dressing from biopolymer mixed with Thai herbal extracts has been formulated. The first layer of bacterial cellulose raised with coconut juice provides not only moisture during the healing process, thereby reducing irritation upon peeling it off, but also matrix to absorb exudates from the wound. The second layer consists of polylactic acid nanofiber prepared via electrospinning process; it also contains antioxidants from rice extracts and antibacterial essential oils from Crofton weed. This wound dressing also exhibits good safety profile toward human skin as both rice extracts and essential oils are non-cytotoxic against human dermal fibroblasts and human keratinocytes. The development has relied on local materials, thereby reducing the costs of imports and strengthening the local industry in wound dressing to effectively cater to the patients’ needs.        The eggshell-derived hydroxyapatite-incorporated fibroin-alginate composite injectable hydrogel has been fabricated as scaffold for bone...

Compounds of natural/semi-synthetic/fully synthetic origins have been screened for their biological activities including but not limited to cytotoxicity with an emphasis against a panel of cancer cell lines, antimicrobial, anti-inflammatory, and antiviral activities. More importantly, advanced techniques in computational chemistry such as molecular docking have been employed to gain insights and understanding of interactions between the biomolecular target(s) and the small molecule drug compounds which could lead to designing more efficacious drug-like candidates with fewer adverse side effects. Moreover, in order to ascertain new candidates with safer drug-like profiles, toxicity against relevant normal cell types has been determined. The ratios of efficacy over general toxicity, namely therapeutic indices (TI) or selectivity indices (SI), are also derived. These values are pivotal for candidate selection since a number of potential drug-like compounds may not advance to further stages including clinical trials because of the inherent general toxicity. Therefore, evaluating both efficacy and toxicity is important in advancing drug candidates through successful drug discovery process.

Previous Next The typical first stage of rational drug design involves the search for molecular templates from which more desirable candidates can be accessed via direct structural modifications orde novosynthesis. On the basis of herbal or folk medicines worldwide, natural products, with their unimaginably complex novel skeletons, have served as both concrete entities and inspiration to learn from as well as to design the better analogs with an aid of modern computational chemistry techniques. Various clinically used herbal remedies with their known bioactive components have been our focus to establish the fully integrated approach for herbs, featuring the development of simplified and efficient isolation processes suitable for industrial applications. Advanced technologies and instrumentation have enabled the quantitative determination of the natural abundance of major bioactive compounds and the preparation of compound standards for commercialization. In addition, our laboratory has also employed some of these naturally occurring compounds as starting materials for direct derivatizations. As an example, mitragynine, the major alkaloid component inMitragyna speciosa, locally known as Kratom, has been obtained through this approach and employed to prepare the bioactive metabolite, 7-hydroxymitragynine, along with other semi-synthetic analogs. As a crucial alternative to access bioactive natural compounds with low natural abundance, simplified and efficient synthetic methods have also been devised for heterocycles frequently encountered as pharmacophores. Structural...