The IACUC must review all proposed animal use protocols before any animal research can be performed within the CRI research and animal facilities. In reviewing the protocol, the IACUC will consider whether the protocol contains all required management and regulatory elements as defined by the Animal Use Policy and Laboratory Animal Program Description. The IACUC will determine if the proposal contains the following information: a justification of why the treatment/condition is scientifically necessary; a statement demonstrating that the PI performed a thorough search of alternatives to the potentially painful procedures; and standards and practices for pain management, adjuvant use, humane end-point determination, etc. At the same time, the OHS Committee will review and discuss safety matters involving the use of chemical, biohazardous and/or radiological agents or materials in animal protocols to ensure the investigator has appropriately planned to reduce or eliminate the exposure to potentially hazardous agents. After determination by the IACUC that the animal use protocol is complete, the protocol is recommended to the IO (or Vice-President for Research and Academic Affairs in the case that the IO is part of the research team on the protocol) for final approval. After official approval, the IACUC Chair will inform the PI that the study may begin. Links 1. LAC-IACUC Form 500 PROTOCOL COVER SHEET2. LAC-IACUC Form 501 IACUC memorandum to...
Proposed modifications to an approved protocol must be reviewed by the IACUC, and receive final approval from the IO (or Vice-president for Research and Academic Affairs in the case that the IO is part of the research team on the protocol) prior to start of the requested study. Modifications to animal protocols may be classified as minor or major. Minor modifications may include changing doses or routes of administration of a drug, and recording or measuring additional variables in the whole animals that are no more invasive than procedures currently approved under the protocol, and that do not increase the pain category of the protocol. Major modifications are those that require a change in the scientific direction of a protocol, e.g. requiring a greater than 10% increase in the number of test animals, changes in the species of the animals approved on the original protocol, changes in pain severity rating, increases in biohazard level on the protocol, and the addition of multiple minor modifications, or a change in the PI. A new PI for a previously approved and active protocol must submit a training statement with his/her request and a signed assurance statement. The process for reviewing/approving protocol amendments is the same as for reviewing a new protocol. Links 1. LAC-IACUC Form 500 PROTOCOL COVER SHEET2....
Annual review and approval by the CRI-IACUC is required for each protocol to remain active through the approved period (3 years). Annual reviews are generally due at the end of each year and cover the previous fiscal year. Amendments should be incorporated into the body of the text and required literature searches must be updated by the Principle Investigator (PI) via an Annual Review of Animal Protocol (IACUC form 505) submitted to the IACUC Administrator for IACUC review and approval. If animal work is to continue on a protocol after the three-year period, the protocol is required to be rewritten completely and all information updated prior to a full IACUC review. In addition, post approval monitoring (PAM) is randomly conducted by means of: a) Additional reviews conducted as appropriate if and deviations or violations are detected/reported. b) Routine observation of animals by animal care personnel. c) Veterinary care or observation by the Attending Veterinarian.
Previous Next Animal research conducted at CRI includes the search for new anti-malarial drugs, and factors affecting susceptibility to malarial infection; studies on animal models of various types of cancers; toxicity of metals, pesticides and air pollutants; acute and chronic toxicity of chemicals found in natural sources; and the health effects of climate change. The major users of the animal facility are researchers from laboratories of Environmental Toxicology, Pharmacology, Immunology, as well as Translational Research Center.
Previous Next 2 Full-time veterinarians (1 Attending Veterinarian and 1 Clinical Veterinarian) has direct responsibility for ensuring adequate veterinary care and is also responsible for ensuring adequate resources to care for animals; proper methods to prevent diseases; communication regarding animal health issues; advising technical and professional staff on proper animal care and use; ensuring proper care and storage of equipment and supplies; and all other aspects of the veterinary care program. Also, the duties engage in protocol support discussion with investigators and coordinates with the veterinary technician. The veterinary technician and animal caretakers are available during the workday from 9 am to 5 pm. They observe the animals during feeding and/or treatment/protocol-related activities. The animals are observed at least once daily also weekend and holiday. After hours observation or treatment is done on an “as needed” basis, when there is a scheduled protocol or emergency medical attention is required.
Guideline Guide for the care and use of Laboratory Animals (EN) Guide for the care and use of Laboratory Animals (TH) Occupational Health the Care and Use AVMA Guidelines For Euthanasia Document จรรยาบรรณการดำเนินการต่อสัตว์เพื่องานทางวิทยาศาสตร์ พศ2559 Ethical Principles and Guidelines for the Use of Animals พระราชบัญญัติสัตว์เพื่องานทางวิทยาศาสตร์ พ.ศ. 2558 (ฉบับภาษาไทย) พระราชบัญญัติสัตว์เพื่องานทางวิทยาศาสตร์ พ.ศ. 2558 (ฉบับภาษาอังกฤษ) จรรยาบรรณนักวิจัย Researcher’s Code of Ethics ข้อกําหนดจรรยาบรรณการดําเนินการต่อสัตว์เพื่องานทางวิทยาศาสตร์ ข้อกําหนดจรรยาบรรณการดําเนินการต่อสัตว์เพื่องานทางวิทยาศาสตร์ (ฉบับที่2) พ.ศ.2560 Link 1.The Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) 2.Thai Association for Laboratory Animal Science (TALAS) 3.สถาบันพัฒนาการดำเนินการต่อสัตว์เพื่องานทางวิทยาศาสตร์ (สพสว.) 4.American Association for Laboratory Animal Science learning library (AALAS learning library)
All personnel working with animals are trained prior to commencing work. The LAC provides in-house training on • ethics and welfare in animal experimentation • protocol writing • animal handling, basic techniques and related procedures to investigators and technical staff • on the job training in animal husbandry • standard operating procedures (SOPs) related to individual task • specific procedure training programs as requested by investigators CRI’s Occupational Health and Safety (OHS) Office provides annual safety training for CRI employees includes topics such as: General Laboratory Safety and Lab Waste Management, General Biosafety and Blood-borne Pathogens, Chemical Safety, Fire Prevention-Emergency Preparedness and Rescue Plan.
Animal Environment The temperature is regulated at 22±1 °C, with a relative humidity (RH) of 55±10% and air exchange rate is set not to fall below 15 air changes/hr. throughout each 24-hour period. The temperature RH and air exchange rate in each room are monitored and recorded in real time by a computerized monitoring system. Sound level and light intensity is not exceed 85 dB, 325 lux respectively in animal housing area. Ammonia levels should not exceed 25 ppm in any type of animal facility. Animal Supplies Food, drinking water, bedding and nesting are used for all rodents in the LAC. Quality control is scheduled for monitoring both nutritional standard values and contamination by in house or outsource laboratories. The contamination monitoring include microorganism, aflatoxin, pesticides, heavy metals and others that related to specific protocol. Micro- and Macro-Environments Cages and lids, filtered top cages, ventilated cages, water bottles, racks/shelves, laminar flow racks, safety cabinets and other animal equipment are routine sanitized in scheduled frequency. The effectiveness of sanitization procedures is monitored (e.g., water temperature monitoring, sterility test, microbiological monitoring, visual inspections and other indicators) Animal rooms sanitation is monitored using air sampler both during and after animal housing.
Animal research conducted at CRI includes the search for new anti-malarial drugs, and factors affecting susceptibility to malarial infection; studies on animal models of various types of cancers; toxicity of metals, pesticides and air pollutants; acute and chronic toxicity of chemicals found in natural sources; and the health effects of climate change. The major users of the animal facility are researchers from laboratories of Environmental Toxicology, Pharmacology, Immunology, as well as Translational Research Center.
2 Full-time veterinarians (1 Attending Veterinarian and 1 Clinical Veterinarian) has direct responsibility for ensuring adequate veterinary care and is also responsible for ensuring adequate resources to care for animals; proper methods to prevent diseases; communication regarding animal health issues; advising technical and professional staff on proper animal care and use; ensuring proper care and storage of equipment and supplies; and all other aspects of the veterinary care program. Also, the duties engage in protocol support discussion with investigators and coordinates with the veterinary technician. The veterinary technician and animal caretakers are available during the workday from 9 am to 5 pm. They observe the animals during feeding and/or treatment/protocol-related activities. The animals are observed at least once daily. After hours observation or treatment is done on an “as needed” basis, when there is a scheduled protocol or emergency medical attention is required.
Previous Next The animal facility is located at the Chulabhorn Research Institute. The facility is housed in one separate 5-storey building that is connected to the Biomedical Research Building on the Mezzanine and 2nd floors at the ends of 2 wings. The total area is approximately 2,660 square meters. The animal facility is a clean conventional facility. There are separate corridors designated as clean or dirty, and a 1-way workflow through the animal rooms. The ground floor is an open lobby external to the building. The Mezzanine floor is a support area for the building that contains the cage wash area, feed and bedding storage areas, drinking water preparation area, animal receiving room, and laundry area. It also houses the air handling units that serve the Mezzanine floor. The second floor is for general animal research. The third floor is non- clinical GLP study facility. The fourth floor is for inhalation toxicology. The fifth floor houses the air handling units that serve the second, third and fourth floors. Access to the building is restricted to only those who are conducting work in the LAC, which includes LAC personnel, researchers and maintenance personnel.
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