Name: Ms. Tharakarn Srisuporn Office address: Translational research unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5541900 ext. 2824 (office), +6684-4227989 (mobile) Position: Researcher scientist, Translational research unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests 1. Molecular technique 2. Mammalian cell culture, cell line development for recombinant protein production 3. Upstream process development and process scale-up 4. Protein purification and qualification Education and Degrees – B.Sc. in Biotechnology, Thammasat University, Bangkok, Thailand (2006) – M.Sc. in Biotechnology, Thammasat University, Bangkok, Thailand (2009) Presentations – Tharakarn Srisuporn, Panida Unakul, Chanan Phonprapai “The Influence of Carbon Source on Arachidonic acid Production by Mortierella Sp. BCC2871 used as Food Supplement for Shrimp Production”, 4th International Conference on Innovations in Food Processing Technology and Engineering, Asian Institute of Technology,Thailand. January 19-20, 2009. (oral presentation) – Luechaipanit W, Artpradit C, Srisuporn T, Tianpanich K, Khongmanee A, Ruchirawat M, Fuangthong M., Speeding up monoclonal antibody production by using polyethyleneimine (PEI)-mediated transient gene expression in large-scale bioreactor, The 13th Annual Conference of Center of Excellence on “The Role and Challenges of Environmental Health in National Development”, 2020

Name: Miss Natchaya Chatchavalrat Office address: Translational research Unit, Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-554-1900 ext. 2821, +6685-215-8456 (mobile) Position: Research assistant, Translational research Unit, Chulabhorn Research Institute E-mail: [email protected] Education and Degrees: Kasetsart University (BangKhen campus), 2012-2016 B.Sc. (Microbiology)

Name: Miss Jirawan Waichata Office address: Translational Research Unit, Chulabhorn Graduate Institute, 906 Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2554 1900 ext. 2620 Position: Research assistant, Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Education and Degrees Kasetsart University (Bangkhen campus), 2012-2016 B.Sc. Biochemistry,

Name: Miss Jarunee Kerdwong Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-554-1900 Ext. 2821 (office), +6686-678-7532 (mobile) Fax: – Positions: Research Scientist, Research Laboratory of Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Website: – Research Interests 1. Protein interaction and characterization 2. Biologics characterization 3. Bioburden monitoring and control in Pharmaceutical facilities Education and Degrees: • Faculty of Mass Communication, Ramkhamhaeng University, 2004-2010 – B.A Mass Communication • Faculty of Medical Science, Naresuan University, 2005-2008 – B.Sc Microbiology, Naresuan University, Thailand, 2008 • Faculty of Science, Mahidol University, 2010-2013 – M.Sc Biotechnology (Molecular Biology), Mahidol University, Thailand, 2013 Academic Positions – Academic Activities International Activities – Local Activities – Professional Societies – Fellowships – International Awards & Honours – Local Awards & Honours – Royal Decorations – ORCID iD (if available): https://orcid.org/0000-0003-1283-8997

Name: Miss Kamolchanok Tianpanich Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5538555 ext. 2821, +66897668495 (mobile) Fax: – Positions: Research scientist, Research Laboratory of Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Website: – Research Interests 1. Research and development of biologics 2. Protein characterization by High performance liquid chromatography (HPLC) Education and Degrees: – B.Sc. in Chemistry (1st class honor), Srinakarinwirot University, Bangkok, Thailand (2008) – M.Sc. in Chemical Biology (International program), Chulabhorn Graduate Institute, Bangkok, Thailand (2010) Publications: 1. Tianpanich, K.; Prachya, S.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp., J. Nat. Prod., 2011, 74 (1), pp 79–81. Presentation: 1. Luechaipanit W, Artpradit C, Srisuporn T, Tianpanich K, Khongmanee A, Ruchirawat M, Fuangthong M., Speeding up monoclonal antibody production by using polyethyleneimine (PEI)-mediated transient gene expression in large-scale bioreactor, The 13th Annual Conference of Center of Excellence on “The Role and Challenges of Environmental Health in National Development”, 2020 2. Tit-oon P, Khongmanee A, Tianpanich K, Piwkam A, Wajeesaksit S, Ruchirawat M, Fuangthong M., Enhanced antibody production by lowering culture temperature of suspension HEK293 cells, 17th International Symposium of the Protein Society of Thailand,...

Name: Miss Phairin Piewtongon Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5541900 ext. 2821 (office), +6683-8121265 (mobile) Position: Research Assistant, Research Laboratory of Translation Research Unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests Research and development of biologics. Downstream processing in pharmaceutical manufacturing. Chromatographic systems for downstream processing. Education and Degrees Bachelor’s degree of Biological Science, Kasetsart University, 2010 Work Experience Protein purification part responsible for downstream process development in R&D scale, resin screening, design of experiments (DoE), optimization, robustness, etc. Responsible for development, documentation, scale-up, process development and transfer of processes to production. Control and optimization of the production processes of purification and isolation of the monoclonal antibody, process technologies and products in the DSP (downstream processing) department at pilot scale. Work with chromatographic systems, perform filtrations, final concentration of the product, implementation of the process of filling of the active substance, participation in the optimization of production processes, packing of chromatographic columns etc. Laboratory/Research Skills FPLC (Fast Protein Liquid Chromatography) Filtration Tangential flow filtration (TFF) HPLC (High-performance liquid chromatography) High Pressure Ion Chromatography (HPIC) PCR Molecular Biology Technique Enzyme-linked immunosorbent assay (ELISA) Publications Sallabhan R, Kerdwong J, Dubbs J, Somsongkul K, Whangsuk W, Piewtongon P, Mongkolsuk S, Loprasert S*. The hdhA...

Name: Miss Gatesara Theerawanitchpan Office address: Translational research unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5541900 ext. 2824 (office), +6689-4535622 (mobile) Positions: Researcher scientist, Translational research unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests 1. Molecular technique 2. Mammalian cell culture, cell line development for recombinant protein production 3. Upstream process development and process scale-up 4. Protein purification and qualification Education and Degrees: – B.Sc. in Biotechnology, Mahidol University, Bangkok, Thailand (2007) – M.Sc. in Biotechnology, Mahidol University, Bangkok, Thailand (2011) Work Experience: – Research and development scientist (2008) The Institute of Molecular Bioscience (MB) Center for Vaccine Development, Nakhon Pathom, Thailand – Medical Scientist (2012) Medical Biotechnology Center (MBC), Department of Medical Science, Ministry of Public Health of Thailand, Nonthaburi, Thailand. – Research Scientist (2013 – now) Translational research unit, Chulabhorn Research Institute. Publications: – Theerawanitchpan G, Saengkrit N, Sajomsang W, Gonil P, Ruktanonchai U, Saesoo S, Flegel TW, Saksmerprome V. Chitosan and its quaternized derivative as effective long dsRNA carriers targeting shrimp virus in Spodoptera frugiperda 9 cells. J Biotechnol. 2012; 160(3-4): 97-104. Presentations: – Oral presentation: “Double-stranded RNA-mediated inhibition of shrimp viral gene in Spodoptera frugiperda (Sf9) cells” In: The 7th National Symposium on Marine Shrimp, Twin Lotus Hotel, Nakhon Si Thammarat, Thailand. – Poster presentation: “Double-stranded...

Chulabhorn Research Institute has long been investigating on bioactive compounds with potential medicinal applications from various sources such as marine organisms, microorganisms, and medicinal plants. Bioactive compounds from selected medicinal plants, namely Sesamum indicum, Andrographis paniculata, Gynostemma pentaphyllum, and Euphoria longana, have been focused and show promising therapeutic efficacy. These compounds potentially lead to development of modern drugs and nutraceutical products. Rapid analytical methods for extraction, identification, quantification of phytochemicals, and standardization of the plant extracts are developed. Study on therapeutic efficacy and safety is performed to ensure purity, safety and efficacy of these products. In addition, these standardized plant extracts may be used as value-added ingredients in various food products such as fruit drinks, cooked or canned foods, to enhance their nutritional values and promote good health.

Previous Next Biologics, or biopharmaceutical drugs, are promising treatments with low side effects for several diseases including cancer, immunological disorderand infectious disease. The high cost of biologics treatment causing the low drug accessibility and affordability. Each year Thailand imports approximately 500-1,000 million Baht of these products from many foreign sources. CRI’s Translational Research Unit (TRU) is focusing on translating fundamental scientific research to solve national and global health issues using multidisciplinary cutting-edge technology. Since the pandemic of bird flu in 2004 in Thailand, Her Royal Highness Princess Chulabhorn realized that Thailand was in an urgent need of national health security for self-reliance on therapeutics. Biologics or biological products consist of variety classes of bioactive agents including vaccines, blood products, tissue therapy, cell therapy, gene therapy, and recombinant proteins. TRU main focus is currently on development of recombinant proteins and biologics with potential to be therapeutics, vaccines, diagnostics, and research reagents. Current focus is primarily but not limited to monoclonal antibody, virus like particle, and recombinant peptide hormone. To ensure the seamless transition and preparation of product pipeline, CRI has integrated all necessary steps required for biologics drug development, which are lead screening, lead identification, lead optimization, characterization assay establishment, efficacy demonstration, process development, and proof of concept study. With the lighting speed of technology shift nowadays, CRI has been invested...

Name: Mister Jackapun Kwangjai Office address: Food and Drug Quality Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-553-8287 (office) Positions: Researcher, Food and Drug Quality Unit, Chulabhorn Research Institute E-mail: [email protected] Website: ……………… Research Interests 1. Effects of natural products on animal behavior responses relating to psychological diseases such as anxiety and depression, and Alzheimer’s disease. 2. Effects of the toxicity of natural products on both cellular and rodent levels. Education and Degrees: • Faculty of Science, Prince of Songkla University, 2007-2013 B.Sc., Biology, Prince of Songkla University, Thailand, 2011 M.Sc., Physiology, Prince of Songkla University, Thailand, 2013 Professional Societies (If any) • Member: The Physiological Society of Thailand, 2013-present; Thai Association for Laboratory Animal Science, 2015-present ORCID iD (if available): https://orcid.org/0000-0001-8545-6899 Publications Research Articles in International Journals 1. Cheaha, D., Issuriya, A., Manor, R., Kwangjai, J., Rujiralai, T., & Kumarnsit, E. (2016). Modification of sleep- waking and electroencephalogram induced by vetiver essential oil inhalation. Journal of intercultural ethnopharmacology, 5(1), 72–78. https://doi.org/10.5455/jice.20160208050736. 2. Worasuttayangkurn, L., Nakareangrit, W., Kwangjai, J., Sritangos, P., Pholphana, N., Watcharasit, P., Rangkadilok, N., Thiantanawat, A., & Satayavivad, J. (2019). Acute oral toxicity evaluation of Andrographis paniculata-standardized first true leaf ethanolic extract. Toxicology reports, 6, 426–430. https://doi.org/10.1016/j.toxrep.2019.05.003. 3. Kwangjai, J., Cheaha, D., Manor, R., Sa-Ih, N., Samerphob,...

Name: Karnpob Kanhasut, Ph.D. Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute,54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +6694868-5666 (mobile) Positions: Researcher, Research Laboratory of Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests 1.Nanobody 2.Phage display 3.Pharmaceutical industry Education and Degrees: • B.S.(Hons), Biochemistry, Burapha University, Thailand, 2010-2014 • Ph.D, Applied Biological Sciences, Chulabhorn Graduate Institute, Thailand, 2014-2022 Academic Activities (If any) Local Activities • President, CGI student union, 2015-2016 Fellowships • Travel Fellowship, Visiting graduate student at MIT Koch Institute, 2018-2019 International Awards & Honours • Research Travel Scholarship, Chulabhorn Graduate Institute, 2018 Local Awards & Honours • First Prize Champion’s Trophy Gold Medal Award, Annual conference of center of excellence on environmental health and toxicology, 2015 • Medal Award and Certificate of Academic Excellence, Professor Dr. Tab Nilanidhi Foundation for outstanding B.S. (Biochemistry) student, 2014 ORCID iD (if available): https://orcid.org/0000-0002-0827-2575 Publications, present. A. Research Articles in International Journals 1. Kanhasut K, Tharakaraman K, Ruchirawat M, Satayavivad J, Fuangthong M, Sasisekharan R. Prediction of the structural interface between fibroblast growth factor23 and burosumab using alanine scanning and molecular docking. 2022.

Name: Dr. Jirachai Getpreecharsawas Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5538555 (office), +6663-7230873 (mobile) Fax: +662-5538572 Position: Researcher, Research Laboratory of Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests 1. Microphysiological systems including organoids-on-a-chip for precision medicine and regulatory science 2. Stem cells for regenerative medicine 3. Cancers Education and Degrees: • B.S., Physics, Mahidol University, Thailand, 1997 • Ph.D., Microsystems Engineering, Rochester Institute of Technology, U.S.A., 2015 Professional Societies • Member: Sigma Xi, 2003-present; Biomedical Engineering Society, 2010-present; American Association for the Advancement of Science, 2019-present Fellowships • Postdoctoral Associate, Biomedical Engineering, University of Rochester, Rochester, NY, 2015-2017 • Student Travel Grant, the 41st IEEE Conference on Decision and Control, Las Vegas, NV, 2002 International Awards & Honours • Honorable Mention Award, Graduate Student Research Competition, Sigma Xi – Indiana University Medical Center Chapter, 2003 • Elected Associate Member, Sigma Xi, 2003 Publications A. Research Articles in International Journals 1. Mukaibo, H., Wang, T., Perez-Gonzalez, V.H., Getpreecharsawas, J., Wurzer, J., Lapizco-Encinas, B.H. and McGrath, J.L. (2018) Ultrathin Nanoporous Membranes for Insulator-Based Dielectrophoresis. Nanotechnology 29: 235704. 2. Khire, T.S., Nehilla, B.J., Getpreecharsawas, J., Gracheva, M.E., Waugh, R.E. and McGrath, J.L. (2018) Finite Element Modeling to Analyze TEER Values across Silicon...