Name: Ms. Tharakarn Srisuporn Office address: Translational research unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5541900 ext. 2824 (office), +6684-4227989 (mobile) Position: Researcher scientist, Translational research unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests 1. Molecular technique 2. Mammalian cell culture, cell line development for recombinant protein production 3. Upstream process development and process scale-up 4. Protein purification and qualification Education and Degrees – B.Sc. in Biotechnology, Thammasat University, Bangkok, Thailand (2006) – M.Sc. in Biotechnology, Thammasat University, Bangkok, Thailand (2009) Presentations – Tharakarn Srisuporn, Panida Unakul, Chanan Phonprapai “The Influence of Carbon Source on Arachidonic acid Production by Mortierella Sp. BCC2871 used as Food Supplement for Shrimp Production”, 4th International Conference on Innovations in Food Processing Technology and Engineering, Asian Institute of Technology,Thailand. January 19-20, 2009. (oral presentation) – Luechaipanit W, Artpradit C, Srisuporn T, Tianpanich K, Khongmanee A, Ruchirawat M, Fuangthong M., Speeding up monoclonal antibody production by using polyethyleneimine (PEI)-mediated transient gene expression in large-scale bioreactor, The 13th Annual Conference of Center of Excellence on “The Role and Challenges of Environmental Health in National Development”, 2020

Name: Miss Natchaya Chatchavalrat Office address: Translational research Unit, Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-554-1900 ext. 2821, +6685-215-8456 (mobile) Position: Research assistant, Translational research Unit, Chulabhorn Research Institute E-mail: [email protected] Education and Degrees: Kasetsart University (BangKhen campus), 2012-2016 B.Sc. (Microbiology)

Name: Miss Jirawan Waichata Office address: Translational Research Unit, Chulabhorn Graduate Institute, 906 Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +66 2554 1900 ext. 2620 Position: Research assistant, Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Education and Degrees Kasetsart University (Bangkhen campus), 2012-2016 B.Sc. Biochemistry,

Name: Miss Jarunee Kerdwong Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-554-1900 Ext. 2821 (office), +6686-678-7532 (mobile) Fax: – Positions: Research Scientist, Research Laboratory of Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Website: – Research Interests 1. Protein interaction and characterization 2. Biologics characterization 3. Bioburden monitoring and control in Pharmaceutical facilities Education and Degrees: • Faculty of Mass Communication, Ramkhamhaeng University, 2004-2010 – B.A Mass Communication • Faculty of Medical Science, Naresuan University, 2005-2008 – B.Sc Microbiology, Naresuan University, Thailand, 2008 • Faculty of Science, Mahidol University, 2010-2013 – M.Sc Biotechnology (Molecular Biology), Mahidol University, Thailand, 2013 Academic Positions – Academic Activities International Activities – Local Activities – Professional Societies – Fellowships – International Awards & Honours – Local Awards & Honours – Royal Decorations – ORCID iD (if available): https://orcid.org/0000-0003-1283-8997

Name: Miss Kamolchanok Tianpanich Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5538555 ext. 2821, +66897668495 (mobile) Fax: – Positions: Research scientist, Research Laboratory of Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Website: – Research Interests 1. Research and development of biologics 2. Protein characterization by High performance liquid chromatography (HPLC) Education and Degrees: – B.Sc. in Chemistry (1st class honor), Srinakarinwirot University, Bangkok, Thailand (2008) – M.Sc. in Chemical Biology (International program), Chulabhorn Graduate Institute, Bangkok, Thailand (2010) Publications: 1. Tianpanich, K.; Prachya, S.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp., J. Nat. Prod., 2011, 74 (1), pp 79–81. Presentation: 1. Luechaipanit W, Artpradit C, Srisuporn T, Tianpanich K, Khongmanee A, Ruchirawat M, Fuangthong M., Speeding up monoclonal antibody production by using polyethyleneimine (PEI)-mediated transient gene expression in large-scale bioreactor, The 13th Annual Conference of Center of Excellence on “The Role and Challenges of Environmental Health in National Development”, 2020 2. Tit-oon P, Khongmanee A, Tianpanich K, Piwkam A, Wajeesaksit S, Ruchirawat M, Fuangthong M., Enhanced antibody production by lowering culture temperature of suspension HEK293 cells, 17th International Symposium of the Protein Society of Thailand,...

Name: Miss Phairin Piewtongon Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5541900 ext. 2821 (office), +6683-8121265 (mobile) Position: Research Assistant, Research Laboratory of Translation Research Unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests Research and development of biologics. Downstream processing in pharmaceutical manufacturing. Chromatographic systems for downstream processing. Education and Degrees Bachelor’s degree of Biological Science, Kasetsart University, 2010 Work Experience Protein purification part responsible for downstream process development in R&D scale, resin screening, design of experiments (DoE), optimization, robustness, etc. Responsible for development, documentation, scale-up, process development and transfer of processes to production. Control and optimization of the production processes of purification and isolation of the monoclonal antibody, process technologies and products in the DSP (downstream processing) department at pilot scale. Work with chromatographic systems, perform filtrations, final concentration of the product, implementation of the process of filling of the active substance, participation in the optimization of production processes, packing of chromatographic columns etc. Laboratory/Research Skills FPLC (Fast Protein Liquid Chromatography) Filtration Tangential flow filtration (TFF) HPLC (High-performance liquid chromatography) High Pressure Ion Chromatography (HPIC) PCR Molecular Biology Technique Enzyme-linked immunosorbent assay (ELISA) Publications Sallabhan R, Kerdwong J, Dubbs J, Somsongkul K, Whangsuk W, Piewtongon P, Mongkolsuk S, Loprasert S*. The hdhA...

Name: Miss Gatesara Theerawanitchpan Office address: Translational research unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5541900 ext. 2824 (office), +6689-4535622 (mobile) Positions: Researcher scientist, Translational research unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests 1. Molecular technique 2. Mammalian cell culture, cell line development for recombinant protein production 3. Upstream process development and process scale-up 4. Protein purification and qualification Education and Degrees: – B.Sc. in Biotechnology, Mahidol University, Bangkok, Thailand (2007) – M.Sc. in Biotechnology, Mahidol University, Bangkok, Thailand (2011) Work Experience: – Research and development scientist (2008) The Institute of Molecular Bioscience (MB) Center for Vaccine Development, Nakhon Pathom, Thailand – Medical Scientist (2012) Medical Biotechnology Center (MBC), Department of Medical Science, Ministry of Public Health of Thailand, Nonthaburi, Thailand. – Research Scientist (2013 – now) Translational research unit, Chulabhorn Research Institute. Publications: – Theerawanitchpan G, Saengkrit N, Sajomsang W, Gonil P, Ruktanonchai U, Saesoo S, Flegel TW, Saksmerprome V. Chitosan and its quaternized derivative as effective long dsRNA carriers targeting shrimp virus in Spodoptera frugiperda 9 cells. J Biotechnol. 2012; 160(3-4): 97-104. Presentations: – Oral presentation: “Double-stranded RNA-mediated inhibition of shrimp viral gene in Spodoptera frugiperda (Sf9) cells” In: The 7th National Symposium on Marine Shrimp, Twin Lotus Hotel, Nakhon Si Thammarat, Thailand. – Poster presentation: “Double-stranded...

Name: Karnpob Kanhasut, Ph.D. Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute,54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +6694868-5666 (mobile) Positions: Researcher, Research Laboratory of Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests 1.Nanobody 2.Phage display 3.Pharmaceutical industry Education and Degrees: • B.S.(Hons), Biochemistry, Burapha University, Thailand, 2010-2014 • Ph.D, Applied Biological Sciences, Chulabhorn Graduate Institute, Thailand, 2014-2022 Academic Activities (If any) Local Activities • President, CGI student union, 2015-2016 Fellowships • Travel Fellowship, Visiting graduate student at MIT Koch Institute, 2018-2019 International Awards & Honours • Research Travel Scholarship, Chulabhorn Graduate Institute, 2018 Local Awards & Honours • First Prize Champion’s Trophy Gold Medal Award, Annual conference of center of excellence on environmental health and toxicology, 2015 • Medal Award and Certificate of Academic Excellence, Professor Dr. Tab Nilanidhi Foundation for outstanding B.S. (Biochemistry) student, 2014 ORCID iD (if available): https://orcid.org/0000-0002-0827-2575 Publications, present. A. Research Articles in International Journals 1. Kanhasut K, Tharakaraman K, Ruchirawat M, Satayavivad J, Fuangthong M, Sasisekharan R. Prediction of the structural interface between fibroblast growth factor23 and burosumab using alanine scanning and molecular docking. 2022.

Name: Dr. Jirachai Getpreecharsawas Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5538555 (office), +6663-7230873 (mobile) Fax: +662-5538572 Position: Researcher, Research Laboratory of Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests 1. Microphysiological systems including organoids-on-a-chip for precision medicine and regulatory science 2. Stem cells for regenerative medicine 3. Cancers Education and Degrees: • B.S., Physics, Mahidol University, Thailand, 1997 • Ph.D., Microsystems Engineering, Rochester Institute of Technology, U.S.A., 2015 Professional Societies • Member: Sigma Xi, 2003-present; Biomedical Engineering Society, 2010-present; American Association for the Advancement of Science, 2019-present Fellowships • Postdoctoral Associate, Biomedical Engineering, University of Rochester, Rochester, NY, 2015-2017 • Student Travel Grant, the 41st IEEE Conference on Decision and Control, Las Vegas, NV, 2002 International Awards & Honours • Honorable Mention Award, Graduate Student Research Competition, Sigma Xi – Indiana University Medical Center Chapter, 2003 • Elected Associate Member, Sigma Xi, 2003 Publications A. Research Articles in International Journals 1. Mukaibo, H., Wang, T., Perez-Gonzalez, V.H., Getpreecharsawas, J., Wurzer, J., Lapizco-Encinas, B.H. and McGrath, J.L. (2018) Ultrathin Nanoporous Membranes for Insulator-Based Dielectrophoresis. Nanotechnology 29: 235704. 2. Khire, T.S., Nehilla, B.J., Getpreecharsawas, J., Gracheva, M.E., Waugh, R.E. and McGrath, J.L. (2018) Finite Element Modeling to Analyze TEER Values across Silicon...

Name: Dr. Charlermchai Artpradit Office address: Research Laboratory of Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5538555 (office), +6683-6198686 (mobile) Position: Research Scientist I, Research Laboratory of Translational Research Unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests Biologics drug discovery: Design and screen for lead compound using as a therapeutic drug or vaccine development using bacterial, insect-baculovirus expression system and mammalian expression system (HEK- 293 and CHO cell). Cell line and process development: Performed cell line development for leads candidate of biosimilars as well as new biologics especially for monoclonal antibody. Small scale process optimization using both conventional cell culture as well high throughput robotic screening. During the optimization both single-use technology as well as conventional re-use system were utilized. Process scale-up for fed-batch and perfusion process using stirred-tank bioreactor as well as rocking bioreactor. Drug quality control: Set up and optimization for biologics characterization including ELISA for quantitation and binding assay, cell-based assay, CEX-HPLC, SEC-HPLC for impurity determination as well as for quantitation, titer measurement using Octet, Western-blot, transmission electron microscope, MALDI-TOF etc. Virology work: Propagate virus under BSL-2 condition and perform related testing using virus as a test system for biologics efficacy or production inoculum. Process development and process scale-up: Set-up and optimization for process scale-up...

Name: Dr. Patchara Ngok-ngam Office address: Research Laboratory of Translational Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-5538555 (office), +66869868418 (mobile) Position: Research scientist Research Laboratory of Translational Unit, Chulabhorn Research Institute E-mail: [email protected] Research Interests 1. Nonclinical study of biologics (pharmacokinetics, pharmacodynamics, toxicology) 2. Monoclonal antibody production using hybridoma for detection kit and drug development 3. Anti-drug antibody (ADA) determination, ADA detection method development and validation, ADA detection kit development Education and Degrees • Chiang-Mai University, 2003-2006 – B.Sc. Associated Medical Sciences (Medical Technology), • Mahidol University, 2007-2009 – M.Sc. Biotechnology • Chulabhorn Graduate Institute, 2010-2015 – Ph.D. Applied Biological Science Program Professional Societies • Member: The Association of Medical Technologists of Thailand ( 6765), 2010-present Publications A.Research Articles in International Journals 1. Ngok-Ngam, P., Watcharasit, P., Thiantanawat, A., & Satayavivad, J. (2013). Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells. Cellular & molecular biology letters, 18(1), 58–74. https://doi.org/10.2478/s11658-012-0039-y] 2. Bhubhanil, S., Ruangkiattikul, N., Niamyim, P., Chamsing, J., Ngok-Ngam, P., Sukchawalit, R., & Mongkolsuk, S. (2012). Identification of amino acid residues important for the function of Agrobacterium tumefaciens Irr protein. FEMS microbiology letters, 335(1), 68–77. https://doi.org/10.1111/j.1574-6968.2012.02638.x 3. Ngok-Ngam, P., Ruangkiattikul, N., Mahavihakanont, A., Virgem, S. S.,...

Name : Dr. Phanthakarn Tit-oon, PhD Office address: Translational Research Unit, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand Tel: +662-554-1900 ext. 2617 (office) E-mail: [email protected] Position: Research Scientist, Translational Research Unit, Chulabhorn Research Institute Research Interests: 1. Biopharmaceuticals 2. Research and development 3. Cell-based and ligand binding assays Education and Degrees PhD (Applied Biological Sciences: Environmental Health), Chulabhorn Graduate Institute, Bangkok, Thailand, 2014. MSc (Biochemistry), Mahidol University, Bangkok, Thailand, 2008. BSc (Medical Technology), Chiang Mai University, Chiang Mai, Thailand, 2004. Academic and Research Positions Research Scientist (2018-Present), Translational Research Unit, Chulabhorn Research Institute, Bangkok, Thailand. Postdoctoral Associate (2017-2018), David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Massachusetts, United States. Researcher (2015-2016), Siriraj Metabolomics and Phenomics Center, Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand. Lecturer (2008-2009), Department of Clinical Chemistry, Faculty of Medical Technology, Huachiew Chalermprakiet University, Samutprakan, Thailand. Professional Societies Member: Protein Society of Thailand, 2022-present. Member: The Association of Medical Technologist of Thailand, 2017-present. International Awards & Honours The best poster presentation award (honorable mention) at the 17th International Symposium of the Protein Society of Thailand (PST). Chiang Mai, Thailand. November 2022. The travel award for young investigators at the 12th Human Proteome Organization (HUPO) World Congress. Yokohama, Japan. September 2013. The outstanding abstract award at...