Staff – Organic Synthesis

Dr. Arthit Makarasen

Category Staff - Organic Synthesis
26 Jan 2023
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Name : Dr. Arthit Makarasen (Research Scientist I)
Office Address : Room : R312 / R303A
Laboratory of Organic Synthesis
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel : +66 2553 8555 (ext. 3020)
Email : [email protected]

Research Interests
Total Synthesis
Natural Product
Molecular Docking and Drug Synthesis
Peptide Synthesis

Education
2005-2009 Ph.D Bioagricultural Science, Nagoya University, Japan
2001-2005 M.Sc. Organic Chemistry, Kasetsart University, Thailand
1997-2001 B.A. Chemistry, Srinakharinwirot University, Thailand

Work Experiences
2009 – present Research Scientist, Chulabhorn Research Institute, Thailand

Publications
Selected Publications

  1. Makarasen, A.; Patnin, S.; Vijitphan, P.; Reukngam, N.; Khlaychan, P.; Kuno, M.; Intachote, P.; Saimanee, B.; Sengsai, S.; Techasakul, S. Structural Basis of 2-Phenylamino-4-phenoxyquinoline Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. Molecules 2022, 27, 461.
  2. Patnin, S; Makarasen, A.; Kuno, M.; S. Techasakul; Vijitphan, P.; Baicharoen, A.  Computational Screening of Phenylamino-phenoxy-quinoline Derivatives against the Main Protease of SARS-COV-2 Using Molecular Docking and the ONIOM Method. Molecules 2022, 27, 1793.
  3. Vijitphan, P.; Makarasen, A.; Patnin, S.; Baicharoen, A.; Techasakul, S. In Vitro Cytotoxic Activity, Molecular Docking Study, and Chemical Composition of Zingiber cassumunar root oil. ScienceAsia 2022, 48, 596-604.
  4. Suvandee, W.; Teeranachaideekul, V.; Jeenduang, N.; Nooeaid, P.; Makarasen, A.; Chuenchom, L.; Techasakul, S.; Dechtrirat, D. One-Pot and Green Preparation of Phyllanthus emblica Extract/Silver Nanoparticles/Polyvinylpyrrolidone Spray-On Dressing. Polymers (Basel) 2022, 14, 2205.
  5. Sinsup, P.; Teeranachaideekul, V.; Makarasen, A.; Chuenchom, L.; Prajongtat, P.; Techasakul, S.; Yingyuad, P.; Dechtrirat, D. Zingiber cassumunar Roxb. Essential Oil-Loaded Electrospun Poly(lactic acid)/Poly(ethylene oxide) Fiber Blend Membrane for Antibacterial Wound Dressing Application. Membranes (Basel) 2021, 11, 648.
  6. Patnin, S.; Makarasen, A.; Kuno, M.; Deeyohe, S.; Techasakul, S.; Chaivisuthangkura, A. Binding Interaction of Potent HIV-1 NNRTIs, Amino-oxy-diarylquinoline with the Transport Protein Using Spectroscopic and Molecular Docking. Spectrochim. Acta-A: Mol. Biomol. Spectrosc. 2020, 233, 118159.
  7. Wongkanya, R.; Teeranachaideekul, V.; Makarasen, A.; Chuysinuan, P.; Yingyuad, P.; Nooeaid, P.; Techasakul, S.; Chuenchom, L.; Dechtrirat, D. Electrospun Poly(lactic acid) Nanofiber Mats for Controlled Transdermal Delivery of Essential Oil from Zingiber cassumunar Roxb. Mater. Res. Express, 2020, 7, 055305.
  8. Makarasen, A.; Kuno, M.; Patnin, S.; Reukngam, N.; Khlaychan, P.; Deeyohe, S.; Intachote, P.; Saimanee, B.; Sengsai, S.; Boonsri, P.; Chaivisuthangkura, A.; Sirithana, W.; Techasakul, S. Molecular Docking Studies and Synthesis of Amino-Oxy-Diarylquinoline Derivatives as Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Drug Res. 2019, 69, 671–682.
  9. Chuysinuan, P.; Chimnoi, N.; Reuk-ngam, N.; Khlaychan, P.; Makarasen, A.; Wetprasit, N.; Dechtrirat, D.; Supaphol, P.; Techasakul, S. Development of Gelatin Hydrogel Pads Incorporated with Eupatorium adenophorum Essential Oil as Antibacterial Wound Dressing. Polym. Bull. 2019, 76, 701-724.
  10. Makarasen, A.; Reuk-ngam, N.; Khlaychan, P.; Chuysinuan, P.; Isobe, M., Techasakul, S. Mode of Action and Synergistic Effect of Valinomycin and Cereulide with Amphotericin B against Candida albicans and Cryptococcus albidus. J. Mycol. Med. 2018, 28, 112-121.
  11. Makarasen, A.; Reuk-ngam, N.; Chuysinuan, P.; Aonsri, C.; Isobe, M.; Techasakul, S. In Vitro Antimicrobial Activity of Cereulide and Valinomycin Compare with Cyclic D,L-α-Peptides and their Enhanced Effect. Int. J. Pharma. Bio. Sci. 2015, 6, 77-85.
  12. Makarasen, A.; Sirithana, W.; Mogkhuntod, S.; Khunnawutmanotham, N.; Chimnoi, N.; Techasakul, S. Cytotoxic and Antimicrobial Activities of Aporphine Alkaloids Isolated from Stephania venosa (Blume) Spreng. Planta Med. 2011, 77, 1519–1524.
  13. Duangthongyou, T.; Makarasen, A.; Techasakul, S.; Chimnoi, N.; Siripaisarnpipat, S. (-)-Crebanine. Acta Crystallogr., E, 2011, 67, o402.
  14. Makarasen, A.; Nishikawa, T.; Isobe, M. Synthesis of Four Lysine-Linked Cereulide Analogues Showing Ionophoric Activity Towards Potassium Cations as Lead Compounds for Emetic Toxin-Detection by Immunoassays. Synthesis, 2009, 13, 2184–2204.
  15. Makarasen, A.; Yoza, K.; Isobe, M. Higher Structure of Cereulide, an Emetic Toxin from Bacillus cereus, and Special Comparison with Valinomycin, an Antibiotic from Streptomyces fulvissimus. Chem. Asian J. 2009, 4, 688–698.
  16. Isobe, M.; Makarasen, A.; Kuse, M.; Nishikawa, T. Substituent Effect of Imino-O-arenesulfonates, a Coupling Partner in Suzuki-Miyaura Reaction for Substitution of the Pyrazine Ring: A Study for the Synthesis of Coelenterazine Analogs. Bull. Chem. Soc. Jpn. 2009, 82, 870–878.

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