Staff – Natural Products

Dr. Hunsa Prawat

Category Staff - Natural Products
26 Jan 2023
4,126
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Name: Dr. Hunsa Prawat (Research Scientist II)
Office Address: Room : R514A / R503
Laboratory of Medicinal Chemistry
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 2553 8555 (3057, 3061-2)
Email: [email protected]

Research Interests
The chemistry and biological activities of natural products from Thai plants.

Education
1994 – 1998 Ph.D Organic Chemistry, Mahidol University, Thailand
1987 – 1989 M.Sc. Organic Chemistry, Mahidol University, Thailand
1982 – 1986 B.A. Prince of Songkhla University, B.Sc. in Education (Chemistry), Thailand

Work Experiences
1990 – present Research Scientist, Chulabhorn Research Institute, Thailand

Publications
          Selected Publications

  1. Thongnest, S.; Boonsombat, J.;  Keeratichamroen, S.; Lirdprapamongkol, K.; Kaweetripob, W.; Kheawchaum, S.; Mahidol, C.; Svasti, J.; Ruchirawat, S.; Prawat, H. Acetogenins from the Stems of Uvaria micrantha Showing Antiproliferative Effects on HepG2 Liver Cancer Cells. Phytochemistry 2022, 204, 113450.
  2. Kheawchaum, S.; Mahidol, C.; Thongnest, S.; Boonsombat, J.; Batsomboon, P.; Sitthimonchai, S.; Ruchirawat, S.; Prawat, H. Ent-Abietane Diterpenoid Lactone Glycosides
    and a Phenolic Glycoside from Phlogacanthus pulcherrimus Anderson with Cytotoxic and Cancer Chemopreventive Activities. Phytochemistry2022, 201, 113261.
  3. Boonsombat, J.; Thongnest, S.; Kheawchaum, S.; Mahidol, C.; Ruchirawat, S.; Prawat, H. Uvarmicranones A and B, Two New Benzoquinones and Cytotoxic Constituents from the Stems of Uvaria micrantha (A. DC.) Hook. f. & Thomson. Prod. Res 2021, 35(24), 5643-5652.
  4. Kaweetripob, W.; Thongnest, S.; Boonsombat, J.; Kheawchaum, S.; Mahidol, C.; Prawat, H.; Ruchirawat, S. Cytotoxic Isoflavonoids from the Roots of Desmodium velutinum (Willd.) DC. Phytochem Lett.2022, 48, 47-53.
  5. Wongbundit, S.; Mahidol, C.; Kaweetripob, W.; Prachyawarakorn, V.; Eurtivong, C.; Sahakitpichan, P.; Tuntiwachwuttikul, P.; Ruchirawat, S.; Prawat, H. Biscurcudiols, Myrmekioperoxides, and Myrmekiodermaral from the Thai Marine Sponge MyrmekiodermaTetrahedron 2020, 76, 131162.
  6. Kaweetripob, W.; Mahidol, C.; Tuntiwachwuttikul, P.; Ruchirawat, S.; Prawat, H. Cytotoxic Sesterterpenes from Thai Marine Sponge Hyrtios erectus.  Drugs 2018, 16, 474. 
  7. Kaweetripob, W.; Mahidol, C.; Wongbundit, S.; Tuntiwachwuttikul, P.; Ruchirawat, S.; Prawat, H. Sesterterpenes and Phenolic Alkenes from the Thai Sponge Hyrtios erectus. Tetrahedron2018, 74, 316-323.
  8. Kaweetripob, W.; Mahidol, C.; Thongnest, S.; Prawat, H.; Ruchirawat, S.  Polyoxygenated Ursane and Oleanane Triterpenes from Siphonodon celastrineus. Phytochemistry2016, 129, 58-67. 
  9. Prawat, H.; Mahidol, C.; Kaweetripob, W.; Prachyawarakorn, V.; Tuntiwachwuttikul, P.; Ruchirawat, S. Sesquiterpene Isocyanides, Isothiocyanates, Thiocyanates, and Formamides from the Thai Sponge HalichondriaTetrahedron 2016, 72, 4222-4229.
  10. Prawat, H.; Mahidol, C.; Kaweetripob, W.; Intachote, P.; Pisutjaroenpong, S.; Ruchirawat, S. Cytotoxic Steroidal Glycosides from the Whole Plant of Calamus acanthophyllus. Planta Med.2016, 82, 1117-1121.
  11. Kaweetripob, W.; Mahidol, C.; Prawat, H.; Ruchirawat, S. Cyclohexene Long-Chain Fatty Acid Esters from Uvaria dulcis(Dunal). Phytochem Lett. 2015, 12, 248-251.
  12. Wittayalai, S.; Mahidol, C.; Prachyawarakorn, V.; Prawat, H.; Ruchirawat, S.  Terpenoids from the Roots of Drypetes hoaensis and Their Cytotoxic Activities. Phytochemistry2014,
    99    , 121-126.
  13. Kaweetripob, W.; Mahidol, C.; Prawat, H.; Ruchirawat, S. Lupane, Friedelane, Oleanane, and Ursane Triterpenes from the Stem of Siphonodon celastrineusPhytochemistry 2013, 96,
    404-417.
  14. Prawat, H.; Mahidol, C.; Kaweetripob, W.; Wittayalai, S.; Ruchirawat, S. Iodo-Sesquiterpene Hydroquinone and Brominated Indole Alkaloids from the Thai Sponge Smenospongia Tetrahedron 2012, 68, 6881-6886.
  15. Kaweetripob, W.; Mahidol, C.; Prachyawarakorn, V.; Prawat, H.; Ruchirawat, S. 5-Formylfurfuryl Esters from Duabanga grandiflora. Phytochemistry 2012, 76, 78-82.
  16. Prawat, H.; Mahidol, C.; Wittayalai, S.; Intachote, P.; Kanchanapoom, T.; Ruchirawat, S. Nitrogenous Sesquiterpenes from the Thai Marine Sponge HalichondriaTetrahedron 2011, 67, 5651-5655.
  17. Mahidol, C.; Prawat, H.; Sangpetsiripan, S.; Ruchirawat, S. Bioactive Scalaranes from the Thai SpongeHyrtios gumminae.  Nat. Prod. 2009, 72, 1870-1874.
  18. Mahidol, C.; Prawat, H.; Kaweetripob, W.; Ruchirawat, S. Regioisomers of Acylcoumarins from the Flowers of Mammea siamensis.  Prod. Commun. 2007, 2, 557-564. 

 

Other Publications

  1. Bhinija, K.; Srifah Huehne, P.; Prawat, H.; Ruchirawat, S.; Saimanee, B.; Mongkolsuk, S.; Satayavivad, J. The Rhizome of Bulbophylllum orchid is the Rich Source of Cytotoxic Bioactive Compounds, the Potential Anticancer Agents. Afr. J. Bot. 2021, 141, 367-372.
  2. Pailee, P.; Prawat, H.; Ploypradith, P.; Mahidol, C.; Ruchirawat, S.; Prachyawarakorn, V. Atalantiaphyllines A-G, Prenylated Acridones from Atalantia monophylla  and Their Aromatase Inhibition and Cytotoxic Activities. Phytochemistry 2020, 180, 112525. 
  3. Thongnest, S.; Boonsombat, J.; Prawat, H.; Mahidol, C.; Ruchirawat, S. Ailanthusins A-G and nor-Lupane Triterpenoids from Ailanthus triphysa. Phytochemistry 2017, 134, 98-105.
  4. Mahidol, C.; Kittakoop, P.; Prachyawarakorn, V.; Pailee, P.; Prawat, H.; Ruchirawat, S. Recent Investigations of Bioactive Natural Products from Endophytic, Marine-Derived, Insect Pathogenic Fungi and Thai Medicinal Plants. Pure & Appl. Chem. 2014, 86, 979-993.
  5. Youngsa-ad, W.; Ngamrojanavanich, N.; Mahidol, C.; Ruchirawat, S.; Prawat, H.; Kittakoop, P. Diterpenoids from the Roots of Croton oblongifolius. Planta Med. 2007, 73(14), 1491-1494. 
  6. Athikomkulchai, S.; Prawat, H.; Thasana, N.; Ruangrungsi, N.; Ruchirawat, S. COX-1, COX-2 Inhibitors and Antifungal Agents from Croton hutchinsonianus. Pharm. Bull. 2006, 54, 262-264.
  7. Lirdprapamongkol, K.; Mahidol, C.; Thongnest, S.; Prawat, H.; Ruchirawat, S.; Srisomsap, C.; Surarit, R.; Punyarit, P.; Svasti, J. Anti-Metastatic Effects of Aqueous Extract of Helixanthera parasitica. Ethnopharmacol. 2003, 86(2-3), 253-256.
  8. Mahidol, C.; Prawat, H.; Prachyawarakorn, V.; Ruchirawat, S. Investigation of Some Bioactive Thai Medicinal Plants. Rev. 2002, 1, 287-297. 
  9. Mahidol, C.; Prawat, H.; Kaweetripob, W.; Ruchirawat, S. Two New Pyranoflavanones from the Stems of Derris reticulata.  Heterocycles 2002, 57, 1287-1292.
  10. Mahidol, C.; Prawat, H.; Kaweetripob, W.; Ruchirawat, S. Mammea Coumarins from the Flowers of Mammea siamensis. Nat. Prod. 2002, 65, 757-760.
  11. Prawat, H.; Mahidol, C.; Ruchirawat, S. Reinvestigation of Derris reticulata. Biol. 2000, 38(1), 63-67.   
  12. Kaweetripob, W.; Mahidol, C.; Prawat, H.; Ruchirawat, S. Chemical Investigation of Mammea siamensis. Biol. 2000, 38(1), 55-57.
  13. Mahidol, C.; Ruchirawat, S.; Prawat, H.; Wongbundit, S. Cytotoxic Natural Products from Thai plants: A Recent Study. Biol. 2000, 38(1), 6-15.
  14. Mahidol, C.; Ruchirawat, S.; Prawat, H.; Pisutjaroenpong, S.; Engprasert, S.; Chumsri, P.; Tengchaisri, T.; Sirisinha, S.; Picha, P. Biodiversity and Natural Product Drug Discovery. Pure & Appl. Chem. 1998, 70(11), 2065-2072.
  15. Roos, G.; Prawat, H.; Walter, C.U.; Klaiber, I.; Vogler, B.; Guse, J.H.; Kraus, W. New Sesquiterpene Lactones with Antibacterial Activity from Vernonia fastigiate. Planta Med. 1998, 64(7), 673-674.
  16. Mahidol, C.; Prawat, H.; Ruchirawat, S. Natural Products for the Improvement of the Quality of Life. Pure & Appl. Chem. 1997, 69(4), 655-657.
  17. Mahidol, C.; Prawat, H.; Ruchirawat, S. Bioactive Natural Products from Thai Medicinal Plants. Special Publication – Royal Society of Chemistry 1997, 200, 96-105.
  18. Mahidol, C.; Prawat, H.; Ruchirawat, S.; Lihkitwitayawuid, K.; Lin, L-Z.; Cordell, G. A. Prenylated Flavanones from Derris reticulata. Phytochemistry 1997, 45(4), 825-829.
  19. Prawat, H.; Mahidol, C.; Ruchirawat, S.; Prawat, U.; Tuntiwachwuttikul, P.; Tooptakong, U.; Taylor, W.C.; Pakawatchai, C.; Skelton, B.W.; White, A.H. Cyanogenic and Non-Cyanogenic Glycosides from Manihot esculenta. Phytochemistry 1995, 40(4), 1167-73. 

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