Dr. Jittiporn Chaisaingmongkol

Name: Dr. Jittiporn Chaisaingmongkol

Office address: Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute,
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +662-5538555 ext. 3136 (office)
Fax: +662-5538572
Position: Research Scientist I, Research Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute
E-mail: [email protected]

Research Interests

1. Cancer biology and molecular biology (Epigenetics and DNA repair)
2. Integrated and functional genomics of human liver cancer (Hepatocellular carcinoma and cholangiocarcinoma)

Education and Degrees: 

• 2000 – 2006 Diplom Degree (Bachelor and Master degree) Bayerischen Julius-Maximilians-Universitaet Wuerzburg, Wuerzburg, GERMANY
• 2006 – 2011 Doctor of Science (DR. RER. NAT.) Ruperto-Carola University of Heidelberg, Heidelberg, GERMANY

Fellowships

• 2011 Postdoctoral Fellow at the German Cancer Research Center, Heidelberg, GERMANY
• 2013-2016 Visiting fellow at Laboratory of Human Carcinogenesis, National Cancer Institute, National Institute of Health, Bethesda, MD, USA

ORCID iD: https://orcid.org/0000-0001-8019-5562

Publications

1. Ma L, Heinrich S, Wang L, Keggenhoff FL, Khatib S, Forgues M, et al. Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer. Nat Commun. 2022;13(1):7533.
2. Khatib SA, Ma L, Dang H, Forgues M, Chung JY, Ylaya K, et al. Single-cell biology uncovers apoptotic cell death and its spatial organization as a potential modifier of tumor diversity in HCC. Hepatology. 2022;76(3):599-611.
3. Schaffer AA, Dominguez DA, Chapman LM, Gertz EM, Budhu A, Forgues M, et al. Integration of adeno-associated virus (AAV) into the genomes of most Thai and Mongolian liver cancer patients does not induce oncogenesis. BMC Genomics. 2021;22(1):814.
4. Pomyen Y, Budhu A, Chaisaingmongkol J, Forgues M, Dang H, Ruchirawat M, et al. Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma. Sci Rep. 2021;11(1):12097.
5. Hung MH, Lee JS, Ma C, Diggs LP, Heinrich S, Chang CW, et al. Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma. Nat Commun. 2021;12(1):1455.
6. Weigel C, Chaisaingmongkol J, Assenov Y, Kuhmann C, Winkler V, Santi I, et al. DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. Clin Epigenetics. 2019;11(1):67.
7. Kwon SM, Budhu A, Woo HG, Chaisaingmongkol J, Dang H, Forgues M, et al. Functional Genomic Complexity Defines Intratumor Heterogeneity and Tumor Aggressiveness in Liver Cancer. Sci Rep. 2019;9(1):16930.
8. Fako V, Martin SP, Pomyen Y, Budhu A, Chaisaingmongkol J, Franck S, et al. Gene signature predictive of hepatocellular carcinoma patient response to transarterial chemoembolization. Int J Biol Sci. 2019;15(12):2654-63.
9. Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, et al. Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma. Cancer Cell. 2017;32(1):57-70 e3.
10. Scarzello AJ, Jiang Q, Back T, Dang H, Hodge D, Hanson C, et al. LTbetaR signalling preferentially accelerates oncogenic AKT-initiated liver tumours. Gut. 2016;65(10):1765-75.
11. Warta R, Herold-Mende C, Chaisaingmongkol J, Popanda O, Mock A, Mogler C, et al. Reduced promoter methylation and increased expression of CSPG4 negatively influences survival of HNSCC patients. Int J Cancer. 2014;135(11):2727-34.
12. Chaisaingmongkol J, Popanda O, Warta R, Dyckhoff G, Herpel E, Geiselhart L, et al. Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma. Oncogene. 2012;31(49):5108-16.
13. Campos B, Warta R, Chaisaingmongkol J, Geiselhart L, Popanda O, Hartmann C, et al. Epigenetically mediated downregulation of the differentiation-promoting chaperon protein CRABP2 in astrocytic gliomas. Int J Cancer. 2012;131(8):1963-8.