Staff – Natural Products

Dr. Jutatip Boonsombat

Category Staff - Natural Products
26 Jan 2023
2,174
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Name : Dr. Jutatip Boonsombat (Research Scientist I)
Office Address : Room : R514B / R603
Laboratory of Natural Products
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel : +66 2553 8555 (ext. 3054)
Email : [email protected]

Research Interests
Development of synthetic method for heterocyclic natural product skeletons, chemical modification of natural products, and natural product isolation for the discovery of new biological active compounds

Education
2003 – 2008 Ph.D Organic Chemistry Emory University, Atlanta, GA, USA
1999 – 2002 M.Sc. Organic Chemistry Chulalongkorn University, Bangkok, Thailand
1996 – 1999 B.A. Chemistry Chulalongkorn University, Bangkok, Thailand

Work Experiences
2008 – present Researcher, Chulabhorn Research Institute, Thailand
2009 – 2019 Invited lecturer, Chulabhorn Graduated Institute
2010 – 2019 Invited lecturer, Sirindhorn International Institute of Technology, Thammasart University
2003 – 2007 Teaching Assistant, Emory University, Atlanta, GA, USA
2002 – 2003 Research Assistant, Chulabhorn Research Institute
2002 Teaching Assistant, Ramkhamhaeng University, Thailand

Awards
2013 DPST social value award
2009 Visiting Scientist, funded by The Japan Society for the Promotion of Science (JSPS), Nagyoya University, Japan, JSPS- NRCT Core University Program
1999 Distinction with Second Class Honor, Chulalongkorn University, Bangkok, Thailand
1989 – 2002 “Scholarship from The Development and Promotion of Science and Technology Talents Project (DPST), Thailand”

Publications
Selected Publications

  1. Thongnest, S.; Boonsombat, J.; Keeratichamroen, S.; Lirdprapamongkol, K.; Kaweetripob, W.; Kheawchaum, S.; Mahidol, C.; Svasti, J.; Ruchirawat, S.; Prawat, H. Acetogenins from the Stems of Uvaria micrantha and Antiproliferative Effects of Uvamicranin B and Uvarigrin on HepG2 Liver Cancer Cells. Phytochemistry 2022, 204, 113450.
  2. Aekrungrueangkit, C.; Wangngae, S.; Kamkaew, A.; Ardkhean, R.; Thongnest, S.; Boonsombat, J.; Ruchirawat, S.; Khotavivattana, T. Novel Psoralen Derivatives as Anti-breast Cancer Agents, Synthesis and Evaluation of Dark and Light Activated Cytotoxicity. Sci. Rep. 2022, 12, 13487.
  3. Hadsarung, R.; Thongnest, S.; Oekchuae, S.; Chaiyaveij, D.; Boonsombat, J.; Ruchirawat, S. Facile Synthesis of 1-Substituted 4-H Phthalazine, a Versatile Scaffold for Chemically Diverse Phthalazines. Tetrahedron 2022, 121, 132920.
  4. Thongnest, S.; Boonsombat, J. Synthesis and Cytotoxic Activity of Wrightiadione and Its Derivatives. Heterocycles 2022, 105, 576–587.
  5. Booranaseensuntorn, P.; Boonsombat, J.; Mahidol, C.; Reuk-Ngam, N.; Khlaychan, P.; Batsomboon, P.; Techasakul, S.; Thongnest, S.; Ruchirawat, S. Diterpenoids and p-Methoxycinnamic Acid Diol Esters from Kaempferia saraburiensis Picheans. (Zingiberaceae): Structural Assignment of Saraburol and Their Biological Activities. Phytochemistry 2022, 199, 113181.
  6. Kheawchaum, S.; Mahidol, C.; Thongnest, S.; Boonsombat, J.; Batsomboon, P.; Sitthimonchai, S.; Ruchirawat, S.; Prawat, H. Ent-abietane Diterpenoid Lactone Glycosides and a Phenolic Glycoside from Phlogacanthus pulcherrimus T. Anderson with Cytotoxic and Cancer Chemopreventive Activities. Phytochemistry 2022, 201, 113261.
  7. Chawengrum, P.; Boonsombat, J.; Mahidol, C.; Eurtivong, C.; Kittakoop, P.; Thongnest, S.; Ruchirawat S. Diterpenoids with Aromatase Inhibitory Activity from the Rhizomes of Kaempferia elegans. J. Nat. Prod. 2021, 84, 1738–1747.
  8. Boonsombat, J.; Thongnest, S.; Kheawchaum, S.; Mahidol, C.; Ruchirawat, S.; Prawat, H. Uvarmicranones A and B, Two New Benzoquinones and Cytotoxic Constituents from the Stems of Uvaria micrantha (A. DC.) Hook. f. & Thomson. Nat. Prod. Res. 2020, 35, 5643–5652.
  9. Boonsombat, J., Chawengrum P., Mahidol C., Kittakoop P., Ruchirawat S., Thongnest S.  A New 22,26-Seco Physalin Steroid from Physalis angulate. Nat. Prod. Res. 2020, 34, 1097–1104.
  10. Thongnest, S.; Chawengrum, P.; Keeratichamroen, S.; Lirdprapamongkol, K.; Eurtivong, C.; Boonsombat, J.; Kittakoop, P.; Svasti, J.; Ruchirawat, S. Vernodalidimer L. A Sesquiterpene Lactone Dimer from Vernonia extensa and Anti-tumor Effects of Vernodalin, Vernolepin, and Vernolide on HepG2 Liver Cancer Cells. Bioorg. Chem. 2019, 92,103197.
  11.  Boonsombat, J.; Thongnest, S.; Ruchirawat, S. A Concise Approach to Oxo-Dehydrorotenoid by Direct Lactonization and the Total Syntheses of Stemonone, Rotenonone, 6-Oxo-dehydroelliptone, and 6-Oxo-6a,12a,-dehydrodeguelin. Eur. J. Org. Chem. 2019, 19, 2971–2983.
  12. Chawengrum, P.; Boonsombat, J.; Kittakoop, P.; Mahidol, C.; Ruchirawat, S.; Thongnest, S. Cytotoxic and Antimicrobial Labdane and Clerodane Diterpenoids from Kaempferia elegans and Kaempferia pulchra. Phytochem. Lett. 2018, 24, 140–144.
  13. Thongnest, S.; Boonsombat, J.; Prawat, H.; Mahidol, H.; Ruchirawat, S. Ailanthusins A-G and nor-Lupane Triterpenoids from Ailanthus triphysa. Phytochemistry 2017, 134, 98–105.
  14. Boonsombat, J.; Prachyawarakorn, V.; Pansanit, A.; Mahidol, C.; Ruchirawat, S.; Thongnest, S. Superbanone, A New 2-aryl-3-benzofuranone and Other Bioactive Constituents from the Tube Roots of Butea superba. Chem Biodivers. 2017, e1700044.
  15. Boonsombat, J.; Mahidol, C.; Chawengrum, P.; Reuk-Ngam, N.; Chimnoi, N.; Techasakul, S.; Ruchirawat, S.; Thongnest, S. Roscotanes and Roscoranes; Oxygenated Abietane and Pimarane Diterpenoids from Kaempferia roscoeana. Phytochemistry 2017, 143, 36–44.
  16. Bensulong, S.; Boonsombat, J.; Ruchirawat, S. DBU-mediated Regioselective Intramolecular Cyclization/Dehydration of ortho-Diketo Phenoxyethers: A Synthesis of 2,3-Substituted γ-Benzopyranones. Tetrahedron 2013, 69, 9335–9348.
  17. Boonsombat, J.; Padwa, A. An IMDAF Cycloaddition Approach toward the Synthesis of the Lycopodium Alkaloid (±)-Fawcettidine. J. Org. Chem. 2011, 76, 2753–2761.
  18. France, S.; Boonsombat, J.; Leverett, C. A.; Padwa, A. Cycloaddition across the Benzofuran Rings as an Approach to the Morphine Alkaloids. J. Org. Chem. 2008, 73, 8120–8123.
  19. Boonsombat, J.; Zhang, H.; Chughtai, M. J.; Hartung, J.; Padwa, A. A General Synthetic Entry to the Pentacyclic Strychnos Alkaloid Family, using a [4 + 2]-Cycloaddition/Rearrangement Cascade Sequence. J. Org. Chem. 2008, 73, 3539–3550.
  20. Padwa, A.; Chughtai, M. J.; Boonsombat, J.; Rashatasakhon, P. A Rh(II)-catalyzed Cycloaddition Approach toward the Synthesis of Komaroviquinone. Tetrahedron 2008, 64, 4758–4767.
  21. Padwa, A.; Boonsombat, J.; Rashatasakhon, P. An Approach toward Oxidopyrylium Ylides using Rh(II)-Catalyzed Cyclization Chemistry. Tetrahedron Lett. 2007, 48, 5938–5941.
  22. Zhang, H.; Boonsombat, J.; Padwa, A. Total Synthesis of (±)-Strychnine via a [4 + 2]-Cycloaddition/Rearrangement Cascade. Org. Lett. 2007, 9, 279–282.
  23. Padwa, A.; Boonsombat, J.; Rashatasakhon, P.; Willis, J. Efficient Construction of the Oxatricyclo [6.3.1.00,0]dodecane Core of Komaroviquinone using a Cyclization/Cycloaddition Cascade of a Rhodium Carbenoid Intermediate. Org. Lett. 2005, 7, 3725–3727.
  24. Bates, R. W.; Boonsombat, J. Synthesis of (+)-Sedamine by Tethered Cyclofunctionalisation. Org. Biomol. Chem. 2005, 3, 520–523.
  25. Bates, R. W.; Boonsombat, J. The Pyridinium Reduction Route to Alkaloids: A Synthesis of (±)-Tashiromine. J. Chem. Soc., Perkin Trans. 1 2001, 7, 654–656.

Other Publications

  1. Oekchuae, S.; Sirirak, J.; Charoensuksai, P.; Wongprayoon, P.; Chuaypen, N.; Boonsombat, J.; Ruchirawat, S.; Tangkijvanich, P.; Suksamrarn, A.; Limpachayaporn, P. The Design and Synthesis of a New Series of 1,2,3-Triazole-Cored Structures Tethering Aryl Urea and Their Highly Selective Cytotoxicity toward HepG2. Pharmaceuticals 2022, 15, 504.
  2. Kaweetripob, W.; Thongnest, S.; Boonsombat, J.; Kheawchaum, S.; Mahidol, C.; Prawat, H.; Ruchirawat, S. Cytotoxic Isoflavonoids from the Roots of Desmodium velutinum (Willd.) DC. Phytochem. Lett. 2022, 48, 47–53.
  3. Keeratichamroen, S.; Lirdprapamongkol, K.; Thongnest, S.; Boonsombat, J.; Chawengrum, P.; Sornprachum, T.; Sirirak, J.; Verathamjamras, C.; Ornnork, N.; Ruchirawat, S.; Svasti, J.  JAK2/STAT3‑Mediated Dose‑dependent Cytostatic and Cytotoxic Effects of Sesquiterpene Lactones from Gymnanthemum extensum on A549 Human Lung Carcinoma Cells. Oncol. Rep. 2021, 47, 6. doi.org/10.3892/or.2021.8217.
  4. Palakhachane, S.; Ketkaew Y.; Chuaypen, N.; Sirirak, J.; Boonsombat, J.; Ruchirawat, S.; Tangkijvanich, P.; Suksamrarn, A.; Limpachayaporn, P. Synthesis of Sorafenib Analogues Incorporating a 1,2,3-Triazole Ring and Cytotoxicity towards Hepatocellular Carcinoma Cell Lines. Bioorg. Chem. 2021, 112, 104831.
  5. Matako, Y.; Suttisingtong, K.; Boonsombat, J.; Sirirak, J.; Limpachayaporn, P. The Synthetic Pathways of a New 1,2,3-Triazole-Containing Sorafenib Analogue and Its Cytotoxicity towards Cancer Cell Lines. rmutsvrj 2021, 13, 244–258.
  6. Nakazaki, A.; Huang, W.-Y.; Koga, K.; Yingyongnarongkul, B.-E.; Boonsombat, J.; Sawayama, Y.; Tsujimoto, T.; Nishikawa, T. Structural Study on a Naturally Occurring Terphenyl Quinone. Biosci. Biotechnol. Biochem. 2013, 77, 1529–1532.
  7. Bates, R. W.; Boonsombat, J.; Lu, Y.; Nemeth, J. A.; Sa-Ei, K.; Song, P.; Cai, M. P.; Cranwell, P. B.; Winbush, S. N,O-Heterocycles as Synthetic Intermediates. Pure Appl. Chem. 2008, 80, 681–685.
  8. Plemper, R. K.; Erlandson, K. J.; Lakdawala, A. S.; Sun, A.; Prussia, A.; Boonsombat, J.; Aki-Sener, E.; Yalcin, I.; Yildiz, I.; Temiz-Arpaci, O.; Tekiner, B.; Liotta, D. C.; Snyder, J. P.; Compans, R. W. A Target Site for Template-Based Design of Measles Virus Entry Inhibitors. Proc. Natl. Acad. Sci. USA 2004, 101, 5628–5633.

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