Dr. Kriengsak Lirdprapamongkol

Name: Dr. Kriengsak Lirdprapamongkol

Office address: Laboratory of Biochemistry, 7th floor, Biomedical Science Building Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 2553 8555 (ext. 3239)
Mobile: +66-86-986-4485 Fax: +66-2-553-8572
E-mail: [email protected]

Research Scientist II

Research
Interests Cancer biology, Metastasis, Drug resistance, Hypoxia, Apoptosis, Cell signaling, Drug discovery, Photodynamic therapy, Sonodynamic therapy, Natural products

Education
– B.Sc. (Biotechnology), King Mongkut’s Institute of Technology Ladkrabang, THAILAND
– M.Sc. (Biochemistry), Mahidol University, THAILAND
– Ph.D. (Biochemistry), Mahidol University, THAILAND

Publications

Journal

1. Thongnest S, Boonsombat J, Keeratichamroen S, Lirdprapamongkol K, Kaweetripob W, Kheawchaum S, et al. Acetogenins from the stems of Uvaria micrantha showing antiproliferative effects on HepG2 liver cancer cells. Phytochemistry. 2022;204:113450.

2. Keeratichamroen S, Lirdprapamongkol K, Thongnest S, Boonsombat J, Chawengrum P, Sornprachum T, et al. JAK2/STAT3mediated dosedependent cytostatic and cytotoxic effects of sesquiterpene lactones from Gymnanthemum extensum on A549 human lung carcinoma cells. Oncol Rep. 2022;47(1).

3. Chaiputtanapun P, Lirdprapamongkol K, Thanaussavadate B, Phongphankhum T, Thippong T, Thangsan P, et al. Biphasic Dose-Dependent G0/G1 and G2/M Cell-Cycle Arrest by Synthetic 2,3-Arylpyridylindole Derivatives in A549 Lung Cancer Cells. ChemMedChem. 2022;17(14):e202200127.

4. Saruengkhanphasit R, Butkinaree C, Ornnork N, Lirdprapamongkol K, Niwetmarin W, Svasti J, et al. Identification of new 3-phenyl-1H-indole-2-carbohydrazide derivatives and their structure-activity relationships as potent tubulin inhibitors and anticancer agents: A combined in silico, in vitro and synthetic study. Bioorg Chem. 2021;110:104795.

5. Rodphon W, Laohapaisan P, Supantanapong N, Reamtong O, Ngiwsara L, Lirdprapamongkol K, et al. Synthesis of Isocryptolepine-Triazole Adducts and Evaluation of Their Cytotoxic Activity. ChemMedChem. 2021;16(24):3750-62.

6. Thanaussavadate B, Ngiwsara L, Lirdprapamongkol K, Svasti J, Chuawong P. A synthetic 2,3-diarylindole induces microtubule destabilization and G2/M cell cycle arrest in lung cancer cells. Bioorg Med Chem Lett. 2020;30(1):126777.

7. Pramual S, Lirdprapamongkol K, Jouan-Hureaux V, Barberi-Heyob M, Frochot C, Svasti J, et al. Overcoming the diverse mechanisms of multidrug resistance in lung cancer cells by photodynamic therapy using pTHPP-loaded PLGA-lipid hybrid nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics. 2020;149:218-28.

8. Ornnork N, Kiriwan D, Lirdprapamongkol K, Choowongkomon K, Svasti J, Eurtivong C. Molecular dynamics, MM/PBSA and in vitro validation of a novel quinazoline-based EGFR tyrosine kinase inhibitor identified using structure-based in silico screening. J Mol Graph Model. 2020;99:107639.

9. Nooeaid P, Chuysinuan P, Pengsuk C, Dechtrirat D, Lirdprapamongkol K, Techasakul S, et al. Polylactic acid microparticles embedded porous gelatin scaffolds with multifunctional properties for soft tissue engineering. Journal of Science: Advanced Materials and Devices. 2020;5(3):337-45.

10. Klangjorhor J, Chaiyawat P, Teeyakasem P, Sirikaew N, Phanphaisarn A, Settakorn J, et al. Mycophenolic acid is a drug with the potential to be repurposed for suppressing tumor growth and metastasis in osteosarcoma treatment. Int J Cancer. 2020;146(12):3397-409.

11. Thongnest S, Chawengrum P, Keeratichamroen S, Lirdprapamongkol K, Eurtivong C, Boonsombat J, et al. Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells. Bioorg Chem. 2019;92:103197.

12. Saejia P, Lirdprapamongkol K, Svasti J, Paricharttanakul NM. Perfluorooctanoic Acid Enhances Invasion of Follicular Thyroid Carcinoma Cells Through NF-kappaB and Matrix Metalloproteinase-2 Activation. Anticancer Res. 2019;39(5):2429-35.

13. Chuysinuan P, Pengsuk C, Lirdprapamongkol K, Techasakul S, Svasti J, Nooeaid P. Enhanced Structural Stability and Controlled Drug Release of Hydrophilic Antibiotic-Loaded Alginate/Soy Protein Isolate Core-Sheath Fibers for Tissue Engineering Applications. Fiber Polym. 2019;20(1):1-10.

14. Singhirunnusorn P, Moolmuang B, Lirdprapamongkol K, Ruchirawat M. Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species. J Toxicol Sci. 2018;43(2):159-69.

15. Samutprasert P, Chiablaem K, Teeraseranee C, Phaiyarin P, Pukfukdee P, Pienpinijtham P, et al. Epigallocatechin gallate-zinc oxide co-crystalline nanoparticles as an anticancer drug that is non-toxic to normal cells. Rsc Adv. 2018;8(14):7369-76.

16. Saharat K, Lirdprapamongkol K, Chokchaichamnankit D, Srisomsap C, Svasti J, Paricharttanakul NM. Tumor Susceptibility Gene 101 Mediates Anoikis Resistance of Metastatic Thyroid Cancer Cells. Cancer Genomics Proteomics. 2018;15(6):473-83.

17. Raungrut P, Wongkotsila A, Champoochana N, Lirdprapamongkol K, Svasti J, Thongsuksai P. Knockdown of 14-3-3gamma Suppresses Epithelial-Mesenchymal Transition and Reduces Metastatic Potential of Human Non-small Cell Lung Cancer Cells. Anticancer Res. 2018;38(6):3507-14.

18. Pruksakorn D, Klangjorhor J, Lirdprapamongkol K, Teeyakasem P, Sungngam P, Chaiyawat P, et al. Oncogenic roles of serine-threonine kinase receptor-associated protein (STRAP) in osteosarcoma. Cancer Chemother Pharmacol. 2018;82(6):1039-47.

19. Prangsaengtong O, Jantaree P, Lirdprapamongkol K, Svasti J, Koizumi K. Shikonin Suppresses Lymphangiogenesis via NF-kappaB/HIF-1alpha Axis Inhibition. Biol Pharm Bull. 2018;41(11):1659-66.

20. Prangsaengtong O, Jantaree P, Lirdprapamongkol K, Ngiwsara L, Svasti J, Koizumi K. Aspirin suppresses components of lymphangiogenesis and lymphatic vessel remodeling by inhibiting the NF-kappaB/VCAM-1 pathway in human lymphatic endothelial cells. Vasc Med. 2018;23(3):201-11.

21. Netsirisawan P, Chaiyawat P, Chokchaichamnankit D, Lirdprapamongkol K, Srisomsap C, Svasti J, et al. Decreasing O-GlcNAcylation affects the malignant transformation of MCF-7 cells via Hsp27 expression and its O-GlcNAc modification. Oncol Rep. 2018;40(4):2193-205.

22. Kuljittichanok D, Diskul-Na-Ayudthaya P, Weeraphan C, Chokchaichamnankit D, Chiablaem K, Lirdprapamongkol K, et al. Effect of Derris scandens extract on a human hepatocellular carcinoma cell line. Oncol Lett. 2018;16(2):1943-52.

23. Keeratichamroen S, Lirdprapamongkol K, Svasti J. Mechanism of ECM-induced dormancy and chemoresistance in A549 human lung carcinoma cells. Oncol Rep. 2018;39(4):1765-74.

24. Wongkanya R, Chuysinuan P, Pengsuk C, Techasakul S, Lirdprapamongkol K, Svasti J, et al. Electrospinning of alginate/soy protein isolated nanofibers and their release characteristics for biomedical applications. Journal of Science Advanced Materials and Devices. 2017;2(3):309-16.

25. Subhasitanont P, Chokchaichamnankit D, Chiablaem K, Keeratichamroen S, Ngiwsara L, Paricharttanakul NM, et al. Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells. Oncol Lett. 2017;14(4):4361-71.

26. Pramual S, Lirdprapamongkol K, Svasti J, Bergkvist M, Jouan-Hureaux V, Arnoux P, et al. Polymer-lipid-PEG hybrid nanoparticles as photosensitizer carrier for photodynamic therapy. J Photochem Photobiol B. 2017;173:12-22.

27. Nooeaid P, Chuysinuan P, Techasakul S, Lirdprapamongkol K, Svasti J. Physico-Chemical and In Vitro Cytotoxic Properties of Alginate/Soy Protein Isolated Scaffolds for Tissue Engineering. Key Engineering Materials. 2017;757:46-51.

28. Kustiawan PM, Lirdprapamongkol K, Palaga T, Puthong S, Phuwapraisirisan P, Svasti J, et al. Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line. BMC Pharmacol Toxicol. 2017;18(1):32.

29. Ketudat Cairns JR, Champattanachai V, Srisomsap C, Paricharttanakul NM, Verathamjamras C, Lirdprapamongkol K, et al. Conference report: the 5th Asia Pacific Protein Association Conference joint meeting with the 12th International Symposium of the Protein Society of Thailand. Biophys Rev. 2017;9(6):857-60.

30. Jantaree P, Lirdprapamongkol K, Kaewsri W, Thongsornkleeb C, Choowongkomon K, Atjanasuppat K, et al. Homodimers of Vanillin and Apocynin Decrease the Metastatic Potential of Human Cancer Cells by Inhibiting the FAK/PI3K/Akt Signaling Pathway. J Agric Food Chem. 2017;65(11):2299-306.

31. Bissanum R, Lirdprapamongkol K, Svasti J, Navakanitworakul R, Kanokwiroon K. The role of WT1 isoforms in vasculogenic mimicry and metastatic potential of human triple negative breast cancer cells. Biochem Biophys Res Commun. 2017;494(1-2):256-62.

32. Seemork J, Sansureerungsikul T, Sathornsantikun K, Sinthusake T, Shigyou K, Tree-Udom T, et al. Penetration of Oxidized Carbon Nanospheres through Lipid Bilayer Membrane: Comparison to Graphene Oxide and Oxidized Carbon Nanotubes, and Effects of pH and Membrane Composition. ACS Appl Mater Interfaces. 2016;8(36):23549-57.

33. Rukkijakan T, Ngiwsara L, Lirdprapamongkol K, Svasti J, Phetrak N, Chuawong P. A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells. Bioorg Med Chem Lett. 2016;26(9):2119-23.

34. Pramual S, Assavanig A, Bergkvist M, Batt CA, Sunintaboon P, Lirdprapamongkol K, et al. Development and characterization of bio-derived polyhydroxyalkanoate nanoparticles as a delivery system for hydrophobic photodynamic therapy agents. J Mater Sci Mater Med. 2016;27(2):40.

35. Ngokpol S, Suwakulsiri W, Sureram S, Lirdprapamongkol K, Aree T, Wiyakrutta S, et al. Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum). Mar Drugs. 2015;13(6):3567-80.

36. Chaiyawat P, Chokchaichamnankit D, Lirdprapamongkol K, Srisomsap C, Svasti J, Champattanachai V. Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells. Oncol Rep. 2015;34(4):1933-42.

37. Buahorm S, Puthong S, Palaga T, Lirdprapamongkol K, Phuwapraisirisan P, Svasti J, et al. Cardanol isolated from Thai Apis mellifera propolis induces cell cycle arrest and apoptosis of BT-474 breast cancer cells via p21 upregulation. Daru. 2015;23:55.

38. Atjanasuppat K, Lirdprapamongkol K, Jantaree P, Svasti J. Non-adherent culture induces paclitaxel resistance in H460 lung cancer cells via ERK-mediated up-regulation of betaIVa-tubulin. Biochem Biophys Res Commun. 2015;466(3):493-8.

39. Raungrut P, Wongkotsila A, Lirdprapamongkol K, Svasti J, Geater SL, Phukaoloun M, et al. Prognostic significance of 14-3-3gamma overexpression in advanced non-small cell lung cancer. Asian Pac J Cancer Prev. 2014;15(8):3513-8.

40. Chittasupho C, Lirdprapamongkol K, Kewsuwan P, Sarisuta N. Targeted delivery of doxorubicin to A549 lung cancer cells by CXCR4 antagonist conjugated PLGA nanoparticles. Eur J Pharm Biopharm. 2014;88(2):529-38.

41. Chiablaem K, Lirdprapamongkol K, Keeratichamroen S, Surarit R, Svasti J. Curcumin Suppresses Vasculogenic Mimicry Capacity of Hepatocellular Carcinoma Cells through STAT3 and PI3K/AKT Inhibition. Anticancer Res. 2014;34(4):1857-64.

42. Pansanit A, Park EJ, Kondratyuk TP, Pezzuto JM, Lirdprapamongkol K, Kittakoop P. Vermelhotin, an Anti-inflammatory Agent, Suppresses Nitric Oxide Production in RAW 264.7 Cells via p38 Inhibition. J Nat Prod. 2013;76(9):1824-7.

43. Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Maruyama T, Athikomkulchai S, et al. A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep. 2013;30(5):2357-64.

44. Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Athikomkulchai S, Viriyaroj A, et al. Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation. Int J Oncol. 2013;43(1):329-37.

45. Khongmanee A, Lirdprapamongkol K, Tit-Oon P, Chokchaichamnankit D, Svasti J, Srisomsap C. Proteomic analysis reveals important role of 14-3-3sigma in anoikis resistance of cholangiocarcinoma cells. Proteomics. 2013;13(21):3157-66.

46. Sakulterdkiat T, Srisomsap C, Udomsangpetch R, Svasti J, Lirdprapamongkol K. Curcumin Resistance Induced by Hypoxia in HepG2 Cells Is Mediated by Multidrug-resistance-associated Proteins. Anticancer Res. 2012;32(12):5337-42.

47. Lirdprapamongkol K, Chiablaem K, Sila-Asna M, Surarit R, Bunyaratvej A, Svasti J. Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2012;422(3):429-35.

48. Kaewpiboon C, Lirdprapamongkol K, Srisomsap C, Winayanuwattikun P, Yongvanich T, Puwaprisirisan P, et al. Studies of the in vitro cytotoxic, antioxidant, lipase inhibitory and antimicrobial activities of selected Thai medicinal plants. BMC Complement Altern Med. 2012;12:217.

49. Amornwachirabodee K, Chiablaem K, Wacharasindhu S, Lirdprapamongkol K, Svasti J, Vchirawongkwin V, et al. Paclitaxel delivery using carrier made from curcumin derivative: synergism between carrier and the loaded drug for effective cancer treatment. J Pharm Sci. 2012;101(10):3779-86.

50. Suwannateep N, Banlunara W, Wanichwecharungruang SP, Chiablaem K, Lirdprapamongkol K, Svasti J. Mucoadhesive curcumin nanospheres: Biological activity, adhesion to stomach mucosa and release of curcumin into the circulation. J Control Release. 2011;151(2):176-82.

51. Pruksakorn D, Lirdprapamongkol K, Chokchaichamnankit D, Subhasitanont P, Chiablaem K, Svasti J, et al. Metabolic alteration of HepG2 in scaffold-based 3-D culture: Proteomic approach. Proteomics. 2010;10(21):3896-904.

52. Soisuwan S, Warisnoicharoen W, Lirdprapamongkol K, Svasti J. Eco-friendly synthesis of fucoidan-stabilized gold nanoparticles. Amer J Appl Sci. 2010;7:1038-42.

53. Lirdprapamongkol K, Sakurai H, Suzuki S, Koizumi K, Prangsaengtong O, Viriyaroj A, et al. Vanillin Enhances TRAIL-Induced Apoptosis in Cancer Cells through Inhibition of NF-kappa B Activation. In Vivo. 2010;24(4):501-6.

54. Lirdprapamongkol K, Kramb JP, Suthiphongchai T, Surarit R, Srisomsap C, Dannhardt G, et al. Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo. J Agric Food Chem. 2009;57(8):3055-63.

55. Lirdprapamongkol K, Kramb JP, Chokchaichamnankit D, Srisomsap C, Surarit R, Sila-Asna M, et al. Juice of eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo. In Vivo. 2008;22(3):363-8.

56. Lirdprapamongkol K, Sakurai H, Kawasaki N, Choo MK, Saitoh Y, Aozuka Y, et al. Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci. 2005;25(1):57-65.

57. Ketudat Cairns JR, Keeratichamroen S, Sukcharoen S, Champattanachai V, Ngiwsara L, Lirdprapamongkol K, et al. The molecular basis of mucopolysaccharidosis type I in two Thai patients. Southeast Asian J Trop Med Public Health. 2005;36(5):1308-12.

58. Srisomsap C, Sawangareetrakul P, Subhasitanont P, Panichakul T, Keeratichamroen S, Lirdprapamongkol K, et al. Proteomic analysis of cholangiocarcinoma cell line. Proteomics. 2004;4(4):1135-44.

59. Lirdprapamongkol K, Mahidol C, Thongnest S, Prawat H, Ruchirawat S, Srisomsap C, et al. Anti-metastatic effects of aqueous extract of Helixanthera parasitica. J Ethnopharmacol. 2003;86(2-3):253-6.

60. Lirdprapamongkol K, Svasti J. Alkyl glucoside synthesis using Thai rosewood β-glucosidase. Biotechnology Letters. 2000;22(23):1889-94.

Books/Chapters

1. Lirdprapamongkol K, Svasti J, Sakurai H, Saiki I. Anticancer effects of vanillin. In: Preedy VR, editor. Beer in health and disease prevention. Academic Press; 2009. p. 260-270.