Dr. Paratchata Batsomboon

Name : Dr. Paratchata Batsomboon (Research Scientist)
Office Address : Room : R516C / R403A
Laboratory of Medicinal Chemistry
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel : +66 2553 8555 (ext. 3046, 3066)
Email : [email protected]

Research Interests
Synthetic methodology
Medicinal Chemistry in Molecular Modification of Small Molecules
Computational Chemistry in Application of Spectroscopy and Reaction Mechanisms

Education
2010 – 2016 Ph.D Organic Chemistry, Florida State University, U.S.A.
2007 – 2009 M.Sc. Chemical Biology, Chlabhorn Graduate Institute, Thailand
2003 – 2007 B.Sc. Chemistry, First Class Honors, Kasetsart University, Thailand

Work Experiences
2020 – present Research Scientist, Chulabhorn Research Institute, Thailand
2017 – 2019 Postdoctoral Researcher, West Virginia University, U.S.A.
2009 – 2010 Research Assistant, Chulabhorn Research Institute, Thailand

Awards
2007-2009 Chulabhorn Graduate Institute Scholarship
2003-2007 Science Achievement Scholarship of Thailand, SAST
2004-2006 Exceptional Academic Achievement Award, Faculty of Science, Kasetsart University

Publications
Selected Publications

1. Fulo, H.F.; Rueb, N.J.; Gaston, R.; Batsomboon, P.; Ahmed, K.T.; Barrios, A.M.; Dudley, G.B. Synthesis of Illudalic acid and Analogous Phosphatase Inhibitors. Org. Biomol. Chem. 2021, 19, 10596–10600
2. Phumjan, T.; Songthammawat, P.; Jongcharoenkamol, J.; Batsomboon, P.; Ruchirawat, S.; Ploypradith, P. Substituted 9-Anthraldehydes from Dibenzocycloheptanol Epoxides via Acid-Catalyzed Epoxide Opening/Semipinacol Rearrangement. J. Org. Chem. 2021, 86, 13322–13349.
3. Wright, A.K.; Batsomboon, P.; Dai, J.; Hung, I.; Zhou, H.-X.; Dudley, G.B.; Cross, T.A. Differential Binding of Rimantadine Enantiomers to Influenza A M2 Proton Channel. J. Am. Chem. Soc. 2016, 138, 1506–1509.
4. Batsomboon, P.; Dudley, G.B. Synthesis of C1–C15 of Palmerolide A: Tactical Advances that can Lead to Better Design Strategies for Polyketide Synthesis. Tetrahedron Lett. 2016, 57, 3757–3759.
5. Batsomboon, P.; Phakhodee, W.; Ruchirawat, S.; Ploypradith, P. Generation of ortho-Quinone Methides by p-TsOH on Silica and Their Hetero-Diels−Alder Reactions with Styrenes. J. Org. Chem. 2009, 74, 4009–4012.

Other Publications

1. Akkarasereenon, K.; Batsomboon, P.; Ruchirawat, S.; Ploypradith, P. Functionalized Chromans from ortho-Quinone Methides and Arylallenes. J. Org. Chem. 2022, Accepted
2. Kheawchaum, S.; Mahidol, C.; Thongnest, S.; Boonsombat, J.; Batsomboon, P.; Sitthimonchai, S.; Ruchirawat, S.; Prawat, H. Ent-abietane Diterpenoid Lactone Glycosides and a Phenolic Glycoside from Phlogacanthus pulcherrimus T. Anderson with Cytotoxic and Cancer Chemopreventive Activities. Phytochemistry 2022, 201, 113261.
3. Booranaseensuntorn, P.; Boonsombat, J.; Mahidol, C.; Reuk-Ngam, N.; Khlaychan, P.; Batsomboon, P.; Techasakul, S.; Thongnest, S.; Ruchirawat, S. Diterpenoids and p-Methoxycinnamic Acid Diol Esters from Kaempferia saraburiensis Picheans. (Zingiberaceae): Structural Assignment of Saraburol and their Biological Activities. Phytochemistry 2022, 199, 113181.
4. Martin, A.C.; Rogers, J.A.; Batsomboon, P.; Morrison, A.E.; Ramsubhag, R.R.; Popp, B.V.; Dudley, G.B. Benzannulation and Hydrocarboxylation Methods for the Synthesis of a Neopentylene-Fused Analogue of Ibuprofen. ACS Omega 2021, 6, 30108–30114
5. McCullough, B.S.; Batsomboon, P.; Hutchinson, K.B.; Dudley, G.B.; Barrios, A.M. Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions. J. Nat. Prod. 2019, 82, 3386–3393.
6. Duangkamol, C.; Batsomboon, P.; Stiegman, A.E.; Dudley, G.B. Microwave Heating Outperforms Conventional Heating for a Thermal Reaction that Produces a Thermally Labile Product: Observations Consistent with Selective Microwave Heating. Chem. Asian J. 2019, 14, 2594–2597.
7. Hayes, K.E.; Batsomboon, P.; Chen, W.-C.; Johnson, B.D.; Becker, A.; Eschrich, S.; Yang, Y.; Robart, A.R.; Dudley, G.B.; Geldenhuys, W.J.; Hazlehurst, L.A. Inhibition of the FAD Containing ER Oxidoreductin 1 (Ero1) Protein by EN-460 as a Strategy for Treatment of Multiple Myeloma. Bioorg. Med. Chem. 2019, 27, 1479–1488.
8. Rizkallah, R.; Batsomboon, P.; Dudley, G.B.; Hurt, M.M. Identification of the Oncogenic Kinase TOPK/PBK as a Master Mitotic Regulator of C2H2 Zinc Finger Proteins. Oncotarget 2015, 6, 1446–1461.
9. Gold, B.; Batsomboon, P.; Dudley, G.B.; Alabugin, I.V. Alkynyl Crown Ethers as a Scaffold for Hyperconjugative Assistance in Noncatalyzed Azide–Alkyne Click Reactions: Ion Sensing through Enhanced Transition-State Stabilization. J. Org. Chem. 2014, 79, 6221–6232.
10. Batsomboon, P.; Gold, B.A.; Alabugin, I.V.; Dudley, G.B. Tandem Nucleophilic Addition/Fragmentation of Vinylogous Acyl Nonaflates for the Synthesis of Functionalized Alkynes, with New Mechanistic Insight. Synthesis 2012, 44, 1818–1824.
11. Tummatorn, J.; Batsomboon, P.; Clark, R.J.; Alabugin, I.V.; Dudley, G.B. Strain-Promoted Azide–Alkyne Cycloadditions of Benzocyclononynes. J. Org. Chem. 2012, 77, 2093–2097.
12. Radomkit, S.; Sarnpitak, P.; Tummatorn, J.; Batsomboon, P.; Ruchirawat, S.; Ploypradith, P. Pt(IV)-Catalyzed Generation and [4+2]-Cycloaddition Reactions of o-Quinone Methides. Tetrahedron 2011, 67, 3904–3914.
13. Chittchang, M.; Batsomboon, P.; Ruchirawat, S.; Ploypradith, P. Cytotoxicities and Structure-Activity Relationships of Natural and Unnatural Lamellarins toward Cancer Cell Lines. ChemMedChem 2009, 4, 457–465.