Staff – Natural Products

Dr. Sanit Thongnest

Category Staff - Natural Products
26 Jan 2023
1,533
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Name : Dr. Sanit Thongnest (Research Scientist I)
Office Address : Room : R519/R514B
Laboratory of Natural Products
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel : +66 2553 8555 (ext. 3055)
Email : [email protected]

Research Interests
Natural products chemistry
semi-synthesis modification

Education
2010 – 2012 Ph.D Applied Chemistry, Ramkhamhaeng University, Thailand
1994 – 1998 M.Sc. Applied Chemistry, Ramkhamhaeng University, Thailand
1991 – 1994 B.S. Chemistry, Ramkhamhaeng University, Thailand

Work Experiences
2013 – present Research Scientist, Chulabhorn Research Institute, Thailand
2010 – 2012 Research Grants from the Center of Excellence for Innovation in Chemistry (PERCH-CIC PERDO)
2001 – 2003 Visiting researchers, JSPS-NRCT Core University Program, Toyama Medicinal and Pharmaceutical University (TMPU), Japan
1994 – 1998 Teaching assistant, Ramkhamhaeng University

Awards
2001 – 2003 Recipient of Research fellowship from the JSPS-NRCT Core University Program

Publications
Selected Publications

  1. Thongnest, S.; Boonsombat, J.; Keeratichamroen, S.; Lirdprapamongkol, K.; Kaweetripob, W.; Kheawchaum, S.; Mahidol, C.; Svasti, J.; Ruchirawat, S.; Prawat, H. Acetogenins from the Stems of Uvaria micrantha Showing Antiproliferative Effects on HepG2 Liver Cancer Cells. Phytochemistry 2022, 204, 113450.
  2. Aekrungrueangkit, C.; Wangngae, S.; Kamkaew, A.; Ardkhean, R.; Thongnest, S.; Boonsombat, J.; Ruchirawat, S.; Khotavivattana, T. Novel Psoralen Derivatives as Anti-breast Cancer Agents and Their Light-activated Cytotoxicity Against HER2 Positive Breast Cancer Cells. Sci. Rep. 2022, 12, 13487.
  3. Kheawchaum, S.; Mahidol, C.; Thongnest, S.; Boonsombat, J.; Ruchirawat, S.; Prawat, H. Ent-Abietane Diterpenoid Lactone Glycosides and a Phenolic Glycoside from Phlogacanthus pulcherrimus T. Anderson with Cytotoxic and Cancer Chemopreventive Activities. Phytochemistry 2022, 201, 113261.
  4. Hadsarung, R.; Thongnest, S.; Oekchuae, S.; Chaiyaveij, D.; Boonsombat, J.; Ruchirawat, S. Facile Synthesis of 1-Substituted 4-H Phthalazine, a Versatile Scaffold for Chemically Diverse Phthalazines. Tetrahedron 2022, 121, 132920.
  5. Booranaseensuntorn, P.; Boonsombat, J.; Mahidol, C.; Reuk-Ngam, N.; Khlaychan, P.; Batsomboon, P.; Techasakul, S.; Thongnest, S.; Ruchirawat, S. Diterpenoids and p-Methoxycinnamic Acid Diol Esters from Kaempferia saraburiensis Picheans. (Zingiberaceae): Structural Assignment of Saraburol and Their Biological Activities. Phytochemistry 2022, 199, 113181.
  6. Kaweetripob, W.; Thongnest, S.; Boonsombat, J.; Kheawchaum, S.; Mahidol, C.; Prawat, H.; Ruchirawat, S. Cytotoxic Isoflavonoids from the Roots of Desmodium velutinum (Wild.) DC. Phytochem. lett. 2022, 48, 47–53.
  7. Thongnest, S; Boonsombat, J. Synthesis and Cytotoxic Activity of Wrightiadione and Its Derivatives. Heterocycles 2022, 105, 576–587.
  8. Keeratichamroen, S.; Lirdprapamongkol, K.; Thongnest, S.; Boonsombat, J.; Chawengrum, P.; Sornprachum, T.; Sirirak, J.; Verathamjamras, C.; Ornnork, N.; Ruchirawat, S.; Svasti, J. JAK2/STAT3-Mediated Dose-Dependent Cytostatic and Cytotoxic Effects of Sesquiterpene Lactones from Gymnanthemum extensum on A549 Human Lung Carcinoma Cells. J. Oncol. Rep. 2022, 47, 6. https://doi.org/10.3892/or.2021.8217
  9. Peerakam, N.; Thongnest, S.; Phoowiang, P.; Machana, K. Bioassay Guided-Isolation of Phytochemicals and Their Biological Effects of Solvent Extracts of Dill (Anethum graveolens) Aerial Portions. J. Herbs Spices Med. Plants 2022, 28, 1989734.
  10. Chawengrum, P.; Boonsombat, J.; Mahidol, C.; Eurtivong, C.; Kittakoop, P.; Thongnest, S.; Ruchirawat, S. Diterpenoids with Aromatase Inhibitory Activity from the Rhizomes of Kaempferia elegans. J. Nat. Prod. 2021, 84, 1738–1747.
  11. Boonsombat, J.; Thongnest, S.; Kheawchaum, S.; Mahidol, C.; Ruchirawat, S.; Prawat, H. Uvarmicranones A and B, Two New Benzoquinones and Cytotoxic Constituents from the Stems of Uvaria micrantha (A. DC.) Hook. f. & Thomson. Nat. Prod. Res. 2021, 35, 5643-5652.
  12. Poolchanuan, P.; Unagul, P.; Thongnest, S.; Wiyakrutta, S.; Ngamrojanavanich, N.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. An Anticonvulsive Drug, Valproic Acid (valproate), has Effects on the Biosynthesis of Fatty Acids and Polyketides in Microorganisms. Sci. Rep. 2020, 10, 9300.
  13. Boonsombat, J.; Chawengrum, P.; Mahidol, C.; Kittakoop, P.; Ruchirawat, S.; Thongnest, S. A New 22,26-Seco Physalin Steroid from Physalis angulata. Nat. Prod. Res. 2020, 34, 1097–1104.
  14. Thongnest, S.; Chawengrum, P.; Keeratichamroen, S.; Lirdprapamongkol, K.; Eurtivong, C.; Boonsombat, J.; Kittakoop, P.; Svasti, J.; Ruchirawat, S. Vernodalidimer L, a Sesquiterpene Lactone Dimer from Vernonia extensa and Anti-tumor Effects of Vernodalin, Vernolepin, and Vernolide on HepG2 Liver Cancer Cells. Bioorg. Chem. 2019, 103197.
  15. Boonsombat, J.; Thongnest, S.; Ruchirawat, S. A Concise Approach to Oxo-Dehydrorotenoid by Direct Lactonization and the Total Syntheses of Stemonone, Rotenonone, 6-Oxo-dehydroelliptone, and 6-Oxo-6a,12a,-dehydrodeguelin. Eur. J. Org. Chem. 2019, 19, 2971–2983.
  16. Chawengrum, P.; Boonsombat, J.; Kittakoop, P.; Mahidol, C.; Ruchirawat, S.; Thongnest, S. Cytotoxic and Antimicrobial Labdane and Clerodane Diterpenoids from Kaempferia elegans and Kaempferia pulchra. Phytochem. Lett. 2018, 24, 140–144.
  17. Kruakaew, S.; Seeka, C.; Lhinhatrakool, T.; Thongnest, S.; Yahuafai, J.; Piyaviriyakul, S.; Siripong, P.; Sutthivaiyakit, S. Cytotoxic Cardiac Glycoside Constituents of Vallaris glabra Leaves. J. Nat. Prod. 2017, 80, 2987–2996.
  18. Boonsombat, J.; Mahidol, C.; Chawengrum, P.; Reuk-Ngam, N.; Chimnoi, N.; Techasakul, S.; Ruchirawat, S.; Thongnest, S. Roscotanes and Roscoranes: Oxygenated Abietane and Pimarane Diterpenoids from Kaempferia roscoeana. Phytochemistry 2017, 143, 36–44.
  19. Boonsombat, J.; Prachyawarakorn, V.; Pansanit, A.; Mahidol, C.; Ruchirawat, S.; Thongnest, S. Superbanone, A New 2-Aryl-3-Benzofuranone and Other Bioactive Constituents from the Tube Roots of Butea superba. Chem. Biodivers. 2017, 14, e1700044
  20. Thongnest, S.; Boonsombat, J.; Prawat, H.; Mahidol, C; Ruchirawat, S. Ailanthusins A-G and nor-Lupane Triterpenoids from Ailanthus triphysa. Phytochemistry 2017, 134, 98–105.
  21. Kaweetripob, W.; Mahidol, C.; Thongnest, S.; Prawat, H.; Ruchirawat, S. Polyoxygenated Ursane and Oleanane Triterpenes from Siphonodon celastrineus. Phytochemistry 2016, 129, 58–67.
  22. Thongnest, S.; Lhinhatrakool, T.; Wetprasit, N.; Sutthivaiyakit, P.; Sutthivaiyakit, S. Eriosema chinense: A Rich Source of Antimicrobial and Antioxidant. Phytochemistry 2013, 96, 353–359.
  23. Thongnest, S.; Sawangsri, R.; Navakhun, K.; Yahuafai, J.; Siripong, P.; Sutthivaiyakit, S. Oximes of 3-Hydroxyprenylflavanones and Their Cytotoxic Activities. Heterocycles 2012, 85, 2723–2734.
  24. Thongnest, S.; Mahidol, C.; Sutthivaiyakit, S.; Ruchirawat, S. Oxygenated Pimarane Diterpenes from Kaempferia marginata. J. Nat. Prod. 2005, 68, 1632–1636.
  25. Pholphana, N.; Rangkadilok, N.; Thongnest, S.; Ruchirawat, S.; Ruchirawat, M.; Satayavivad, J. Determination and Variation of Three Active Diterpenoids in Andrographis paniculata (Burm.f.) Nees. Phytochem. Anal. 2004, 15, 365–371.
  26. Lirdprapamongkol, K.; Mahidol, C.; Thongnest, S.; Prawat, H.; Ruchirawat, S.; Srisomsap, C.; Surarit, R.; Punyarit, P.; Svasti, J. Anti-metastatic Effects of Aqueous Extract of Helixanthera parasitica. J. Ethnopharmacol. 2003, 86, 253–256.

Other Publications

  1. Peerakam, N.; Thongnest, S.; Phoowiang, P.; Machana, K. Bioassay Guided-Isolation of Phytochemicals and Their Biological Effects of Solvent Extracts of Dill (Anethum graveolens) Aerial Portions. J. Herbs Spices Med. Plants 2022, 28, 1989734.
  2. Kruakaew, S.; Seeka, C.; Lhinhatrakool, T.; Thongnest, S.; Yahuafai, J.; Piyaviriyakul, S.; Siripong, P.; Sutthivaiyakit, S. Cytotoxic Cardiac Glycoside Constituents of Vallaris glabra Leaves. J. Nat. Prod. 2017, 80, 2987–2996.
  3. Thongnest, S.; Lhinhatrakool, T.; Wetprasit, N.; Sutthivaiyakit, P.; Sutthivaiyakit, S. Eriosema chinense: A Rich Source of Antimicrobial and Antioxidant. Phytochemistry 2013, 96, 353–359.
  4. Thongnest, S.; Sawangsri, R.; Navakhun, K.; Yahuafai, J.; Siripong, P.; Sutthivaiyakit, S. Oximes of 3-Hydroxyprenylflavanones and Their Cytotoxic Activities. Heterocycles 2012, 2723–2734.

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