Dr. Siriporn Keeratichamroen
Name: Dr. Siriporn Keeratichamroen
Office address: B705C, 7th Floor, Biomedical Science Building 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 2553 8555 (ext. 3239)
E-mail: [email protected]
Research Scientist I
Research Interests
Cancer Biology, Cell Signaling, Cancer Microenvironment
Education
– B. Sc. Chemistry – Kasetsart University, Bangkok, Thailand
– M. Sc. Molecular Genetics and Genetic Engineering – Mahidol University, Bangkok, Thailand
– Ph. D. Molecular Medicine – Mahidol University, Bangkok, Thailand
Publications
1. Thongnest S, Boonsombat J, Keeratichamroen S, Lirdprapamongkol K, Kaweetripob W, Kheawchaum S, Mahidol C, Svasti J, Ruchirawat S, Prawat H. Acetogenins from the stems of Uvaria micrantha showing antiproliferative effects on HepG2 liver cancer cells. Phytochemistry. 2022 Sep 24;204:113450. doi: 10.1016/j.phytochem.2022.113450. Epub ahead of print. PMID: 36162462.
2. Keeratichamroen S, Lirdprapamongkol K, Thongnest S, Boonsombat J, Chawengrum P, Sornprachum T, Sirirak J, Verathamjamras C, Ornnork N, Ruchirawat S, Svasti J. JAK2/STAT3‑mediated dose‑dependent cytostatic and cytotoxic effects of sesquiterpene lactones from <i>Gymnanthemum extensum</i> on A549 human lung carcinoma cells. Oncol Rep. 2022 Jan;47(1):6. doi: 10.3892/or.2021.8217. Epub 2021 Nov 5. PMID: 34738622; PMCID: PMC8600427.
3. Keeratichamroen S, Subhasitanont P, Chokchaichamnankit D, Weeraphan C, Saharat K, Sritana N, Kantathavorn N, Wiriyaukaradecha K, Sricharunrat T, Paricharttanakul NM, Auewarakul C, Svasti J, Srisomsap C. Identification of potential cervical cancer serum biomarkers in Thai patients. Oncol Lett. 2020 Jun;19(6):3815-3826. doi: 10.3892/ol.2020.11519. Epub 2020 Apr 7.
4. Thongnest S, Chawengrum P, Keeratichamroen S, Lirdprapamongkol K, Eurtivong C, Boonsombat J, Kittakoop P, Svasti J, Ruchirawat S. Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells. Bioorg Chem. 2019 Nov;92:103197. doi: 10.1016/j.bioorg.2019.103197. Epub 2019 Aug 16. PMID: 31445193
5. Chokchaichamnankit D, Watcharatanyatip K, Subhasitanont P, Weeraphan C, Keeratichamroen S, Sritana N, Kantathavorn N, Diskul-Na-Ayudthaya P, Saharat K, Chantaraamporn J, Verathamjamras C, Phoolcharoen N, Wiriyaukaradecha K, Paricharttanakul NM, Udomchaiprasertkul W, Sricharunrat T, Auewarakul C, Svasti J, Srisomsap C. Urinary biomarkers for the diagnosis of cervical cancer by quantitative label-free mass spectrometry analysis. Oncol Lett. 2019 Jun;17(6):5453-5468. doi: 10.3892/ol.2019.10227. Epub 2019 Apr 8. PMID: 31186765
6. Keeratichamroen S, Lirdprapamongkol K, Svasti J. Mechanism of ECM-induced dormancy and chemoresistance in A549 human lung carcinoma cells. Oncol Rep. 2018 Apr;39(4):1765-1774. doi: 10.3892/or.2018.6258. Epub 2018 Feb 12. PMID: 29436672
7. Subhasitanont P, Chokchaichamnankit D, Chiablaem K, Keeratichamroen S, Ngiwsara L, Paricharttanakul NM, Lirdprapamongkol K, Weeraphan C, Svasti J, Srisomsap C. Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells. Oncol Lett. 2017 Oct;14(4):4361-4371. doi: 10.3892/ol.2017.6705. Epub 2017 Aug 2. PMID: 28943950
8. Chiablaem K, Lirdprapamongkol K, Keeratichamroen S, Surarit R, Svasti J. Curcumin suppresses vasculogenic mimicry capacity of hepatocellular carcinoma cells through STAT3 and PI3K/AKT inhibition. Anticancer Res. 2014 Apr;34(4):1857-64. PMID: 24692720
9. Moolthiya P, Tohtong R, Keeratichamroen S, Leelawat K. Role of mTOR inhibitor in cholangiocarcinoma cell progression. Oncol Lett. 2014 Mar;7(3):854-860. doi: 10.3892/ol.2014.1799. Epub 2014 Jan 15. PMID: 24527093
10. Leelawat K, Keeratichamroen S, Leelawat S, Tohtong R. CD24 induces the invasion of cholangiocarcinoma cells by upregulating CXCR4 and increasing the phosphorylation of ERK1/2. Oncol Lett. 2013 Nov;6(5):1439-1446. Epub 2013 Sep 17. PubMed PMID: 24179538; PubMed Central PMCID: PMC3813815.
11. Charoenwattanasatien R, Cairns JR, Keeratichamroen S, Sawangareetrakul P, Tanpaiboon P, Wattanasirichaigoon D, Pangkanon S, Svasti J, Champattanachai V. Decreasing activity and altered protein processing of human iduronate-2-sulfatase mutations demonstrated by expression in COS7 cells. Biochem Genet. 2012 Dec;50(11-12):990-7. doi: 10.1007/s10528-012-9538-9. Epub 2012 Sep 19. PubMed PMID: 22990955.
12. Vatanavicharn N, Champattanachai V, Liammongkolkul S, Sawangareetrakul P, Keeratichamroen S, Ketudat Cairns JR, Srisomsap C, Sathienkijkanchai A, Shotelersuk V, Kamolsilp M, Wattanasirichaigoon D, Svasti J, Wasant P. Clinical and molecular findings in Thai patients with isolated methylmalonic acidemia. Mol Genet Metab. 2012 Aug;106(4):424-9. doi: 10.1016/j.ymgme.2012.05.012. Epub 2012 May 29. PubMed PMID: 22695176.
13. Keeratichamroen S, Leelawat K, Thongtawee T, Narong S, Aegem U, Tujinda S, Praditphol N, Tohtong R. Expression of CD24 in cholangiocarcinoma cells is associated with disease progression and reduced patient survival. Int J Oncol. 2011 Jun 17. doi: 10.3892/ijo.2011.1088. [Epub ahead of print] PubMed PMID: 21687942.
14. Keeratichamroen S, Ketudat Cairns JR, Wattanasirichaigoon D, Wasant P, Ngiwsara L, Suwannarat P, Pangkanon S, Kuptanon J, Tanpaiboon P, Rujirawat T, Liammongkolkul S, Svasti J. Molecular analysis of the iduronate-2-sulfatase gene in Thai patients with Hunter syndrome. J Inherit Metab Dis. 2008 May 20. [Epub ahead of print] PubMed PMID: 18500569.
15. Suwannarat P, Keeratichamroen S, Wattanasirichaigoon D, Ngiwsara L, Cairns JR, Svasti J, Visudtibhan A, Pangkanon S. Molecular characterization of type 3 (neuronopathic) Gaucher disease in Thai patients. Blood Cells Mol Dis. 2007 Nov-Dec;39(3):348-52. Epub 2007 Aug 8.
16. Keeratichamroen S, Cairns JR, Sawangareetrakul P, Liammongkolkul S, Champattanachai V, Srisomsap C, Kamolsilp M, Wasant P, Svasti J. Novel mutations found in two genes of thai patients with isolated methylmalonic acidemia. Biochem Genet. 2007 Jun;45(5-6):421-30. Epub 2007 Apr 5.
17. Wattanasirichaigoon D, Svasti J, Cairns JR, Tangnararatchakit K, Visudtibhan A, Keeratichamroen S, Ngiwsara L, Khowsathit P, Onkoksoong T, Lekskul A, Mongkolsiri D, Jariengprasert C, Thawil C, Ruencharoen S. Clinical and molecular characterization of an extended family with Fabry disease. J Med Assoc Thai. 2006 Sep;89(9):1528-35.
18. Ketudat Cairns JR, Keeratichamroen S, Sukcharoen S, Champattanachai V, Ngiwsara L, Lirdprapamongkol K, Liammongkolkul S, Srisomsap C, Surarit R, Wasant P, Svasti J. The molecular basis of mucopolysaccharidosis type I in two Thai patients. Southeast Asian J Trop Med Public Health. 2005 Sep;36(5):1308-12.
19. Svasti J, Srisomsap C, Subhasitanont P, Keeratichamroen S, Chokchaichamnankit D, Ngiwsara L, Chimnoi N, Pisutjaroenpong S, Techasakul S, Chen ST. Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis. Proteomics. 2005 Nov;5(17):4504-9.
20. Srisomsap C, Sawangareetrakul P, Subhasitanont P, Panichakul T, Keeratichamroen S, Lirdprapamongkol K, Chokchaichamnankit D, Sirisinha S, Svasti J. Proteomic analysis of cholangiocarcinoma cell line. Proteomics. 2004 Apr;4(4):1135-44.
21. Champattanachai V, Ketudat Cairns JR, Shotelersuk V, Keeratichamroen S, Sawangareetrakul P, Srisomsap C, Kaewpaluek V, Svasti J. Novel mutations in a Thai patient with methylmalonic acidemia. Mol Genet Metab. 2003 Aug;79(4):300-2.
22. Angsuthanasombat C, Sramala L, Puntheeranurak T, Keeratichamroen S, Krittanai C, and Katzenmeier G. Molecular basis of the Bacillus thuringiensis toxin-induced pore structure and permeability. Biophys J. 2002 82 (1), 33 Part 2.
23. Angsuthanasombat C, Keeratichamroen S, Leetacheewa S, Katzenmeier G, Panyim S. Directed mutagenesis of the Bacillus thuringiensis Cry11A toxin reveals a crucial role in larvicidal activity of arginine-136 in helix 4. J Biochem Mol Biol. 2001 Sep;34(5):402-7.
