Staff – Natural Products

Dr. Vilailak Prachyawarakorn

Category Staff - Natural Products
26 Jan 2023
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Name : Dr. Vilailak Prachyawarakorn (Research Scientist II)
Office Address : Room : R503
Laboratory of Natural Products
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel : +66 2553 8555 (ext. 3061-2, 3070)
Email : [email protected]

Research Interests
Natural Products chemistry: Isolation and structural elucidatiion of isolated compounds from Thai plants.
Evaluation of biological activities: Biological assays of secondary metabolites.

Education
2005 – 2001 Ph.D Organic Chemistry, Mahidol University, Thailand
1999 – 1994 M.Sc. Organic Chemistry, Mahidol University, Thailand
1994 – 1990 B.A. Chemistry, Prince of Songkla University, Thailand

Work Experiences
1999 – present Research Scientist, Chulabhorn Research Institute, Thailand

Publications
Selected Publications

  1. Pailee, P.; Ploypradith, P.; Mahidol, C.; Ruchirawat, S.; Prachyawarakorn, V. Dulcisenes C-E, Polyoxygenated Cyclohexenes, from Uvaria dulcis dunal and Their Cytotoxic Activity. Phytochemistry 2022, 202, 113298.
  2. Pailee, P.; Prawat, H.; Ploypradith, P.; Mahidol, C.; Ruchirawat, S.; Prachyawarakorn, V. Atalantiaphyllines A-G, Prenylated Acridones from Atalantia monophylla DC. and Their Aromatase Inhibition and Cytotoxic Activities. Phytochemistry 2020, 180, 112525.
  3. Pailee, P.; Mahidol, C.; Ruchirawat, S.; Prachyawarakorn, V. Diverse Flavonoids from the Roots of Millettia brandisiana. Phytochemistry 2019, 162, 157-164.
  4. Pailee, P.; Mahidol, C.; Ruchirawat, S.; Prachyawarakorn, V. Sterols from Thai Marine Sponge Petrosia (Strongylophora) sp. and Their Cytotoxicity. Mar. Drugs. 2017, 15, 54.
  5. Boonsombat, J.; Prachyawarakorn, V.; Pansanit, A.; Mahidol, C.; Ruchirawat, S.; Thongnest, S. Superbanone, A New 2-Aryl-3-, Benzofuranone and Other Bioactive Constituents from the Tube Roots of Butea superba. Chem. Biodivers. 2017, 14, e1700044.
  6. Wibowo, M.; Prachyawarakorn, V.; Aree, T.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Cytotoxic Sesquiterpenes from the Endophytic Fungus Pseudolagarobasidium acaciicola. Phytochemistry 2016, 122, 126-138.
  7. Darsih, C.; Prachyawarakorn, V.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Cytotoxic Metabolites from the Endophytic Fungus Penicillium chermesinum: Discovery of a Cysteine-Targeted Michael Aacceptor as a Pharmacophore for Fragment-Based Drug Discovery, Bioconjugation and Click Reactions. RSC Adv. 2015, 5(86), 70595-70603.
  8. Pailee, P.; Sangpetsiripan, S.; Mahidol, C.; Ruchirawat, S.; Prachyawarakorn, V. Cytotoxic and Cancer Chemopreventive Properties of Prenylated Stilbenoids from Macaranga siamensis. Tetrahedron 2015, 71(34), 5562-5571.
  9. Pailee, P.; Prachyawarakorn, V.; Ruchirawat, S.; Mahidol, C. Bioactive Cardinane Sesquiterpenes from the Stems of Alangium salviifolium. Chem. Asian J. 2015, 10(4), 910-914.
  10. Dendup, T.; Prachyawarakorn, V.; Pansanit, A.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. α-Glucosidase Inhibitory Activities of Isoflavanones, Isoflavones, and Pterocarpans from Mucuna pruriens, Planta Med. 2014, 80(7), 604-608.
  11. Wibowo, M.; Prachyawarakorn, V.; Aree, T.; Wiyakrutta, S.; Mahidol, C.; Ruchirawat; S.; Kittakoop, P. Tricyclic and Spirobicyclic Norsesquiterpenes from the Endophytic Fungus Pseudolagarobasidium acaciicola. Eur. J. Org. Chem. 2014, 19, 3976–3980.
  12. Bajgai, S. P.; Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Hybrid Flavan-Chalcones, Aromatase and Lipoxygenase Inhibitors from Desmos cochinchinensis. Phytochemistry 2011, 72(16), 2062-2067.
  13. Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S. Longeracemosones A–F, Aromatase Inhibitors from Dunbaria longeracemosa. Eur. J. Org. Chem. 2011, 20-21, 3803–3808.
  14. Pailee, P.; Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Protoberberine Alkaloids and Cancer Chemopreventive Properties of Compounds from Alangium salviifolium. Eur. J. Org. Chem. 2011, 20-21, 3809–3814.
  15. Parks, J.; Gyeltshen, T.; Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S.; Kittakoop, P. Glutarimide Alkaloids and a Terpenoid Benzoquinone from Cordia globifera. J. Nat. Prod. 2010, 73, 992–994.
  16. Prachyawarakorn, V.; Mahidol, C.; Sureram, S.; Sangpetsiripan, S.; Wiyakrutta, S.; Ruchirawat, S.; Kittakoop, P. Diketopiperazines and Phthalides from a Marine Derived Fungus of the Order Pleosporales. Planta Med. 2008, 74(1), 69-72.
  17. Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S. Siamenols A—D, Four New Coumarins from Mammea siamensis. Chem. Pharm. Bull. 2006, 54(6), 884-886.
  18. Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S. Pyranocoumarins from the twigs of Mammea siamensis. Phytochemistry 2006, 67, 924–928.
  19. Prachyawarakorn, V.; Mahidol, C.; Ruchirawat, S. NMR Study of Seven Coumarins from Mammea siamensis. Pharm. Biol. 2000, 38, 58-62.

Other Publications

  1. Wongbundit, S.; Mahidol, C.; Kaweetripob, W.; Eurtivong, C.; Sahakitpichan, P.; Tuntiwachwuttikul, P.; Ruchirawat, S.; Prawat, H. Biscurcudiols, Myrmekioperoxides, and Myrmekiodermaral from the Thai Marine Sponge Myrmekioderma sp. Tetrahedron 2020, 76(19), 131162.
  2. Lelakova, V.; Beraud-Dufour, S.; Hosek, J.; Smejkal, K.; Prachyawarakorn, V.; Pailee, P.; Widmann, C.; Vaclavik, J.; Coppola, T.; Mazella, J.; Blondeau, N.; Heurteaux, C. Therapeutic Potential of Prenylated Stilbenoid Macasiamenene F through its Anti-inflammatory and Cytoprotective Effects on LPS-Challenged Monocytes and Microglia. J. Ethnopharmacol. 2020, 263, 113147.
  3. Hošek, J.; Leláková, V.; Bobál, P.: Pížová, H.; Markéta, G.; Malaník, M.; Jakubczyk, K; Ondřej,V.; Landa, P.; Temml, V.; Schuster, D.; Prachyawarakorn, V.; Pailee, P.; Ren, G.; Zpurný, F.; Oravec, M.; Šmejkal, K. Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-κB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase. J. Nat. Prod. 2019, 82(7), 1839-1848.
  4. Prawat, H.; Mahidol, C.; Kaweetripob, W.; Prachyawarakorn, V.; Tuntiwachwuttikul, P.; Ruchirawat, S. Sesquiterpene Isocyanides, Isothiocyanates, Thiocyanates, and Formamides from the Thai Sponge Halichondria sp. Tetrahedron 2016, 72, 4222-4229.
  5. Mahidol, C.; Kittakoop, P.; Prachyawarakorn, V.; Pailee, P.; Prawat, H.; Ruchirawat, S. Recent Investigations of Bioactive Natural Products from Endophytic, Marine-Derived, Insect Pathogenic Fungi and Thai Medicinal Plants. Pure Appl. Chem. 2014, 86, 979-993.
  6. Wittayalai, S.; Mahidol, C.; Prachyawarakorn, V.; Prawat, H.; Ruchirawat, S. Terpenoids from the Roots of Drypetes hoaensis and Their Cytotoxic Activities. Phytochemistry 2014, 99, 121-126.
  7. Kaweetripob, W.; Mahidol, C.; Prachyawarakorn, V.; Prawat, H.; Ruchirawat, S. 5-Formylfurfuryl Esters from Duabanga grandiflora. Phytochemistry 2012, 76, 78–82.
  8. Markmee, S.; Ruchirawat, S.; Prachyawarakorn, V.; Ingkaninana, K.; Khorana, N. Isoquinoline Derivatives as Potential Acetylcholinesterase Inhibitors. Bioorg. Med. Chem. Lett. 2006, 16, 2170–2172.
  9. Mahidol, C.; Prawat, H.; Prachyawarakorn, V.; Ruchirawat, S. Investigation of Some Bioactive Thai Medicinal Plants. Phytochem. Rev. 2003, 287-297.
  10. Thasana, N.; Prachyawarakorn, V.; Tontoolarug, S.; Ruchirawat, S. Synthesis of Aryl α-Keto Ester via the Rearrangement of Aryl Cyanohydrin Carbonate Esters. Tetrahedron Lett. 2003, 44, 1019-1021.

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