Dr. Wannaporn Disadee

Name : Dr. Wannaporn Disadee (Research Scientist I)
Office Address : Room : R614B/R603
Laboratory of Medicinal Chemistry
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel : +66 2553 8555 (ext. 3081, 3090, 3091)
Email : [email protected]

Research Interests
One-pot Tandem Reaction and Green Synthetic Methodology
Organocatalytic Asymmetric Synthesis
Total Synthesis of Biologically Active N-Heterocycles

Education
2003 – 2006 Ph.D Pharmaceutical Sciences in Medicinal Organic Chemistry, Chiba University, Japan
2001 – 2003 M.Sc. Pharmaceutical Sciences in Medicinal Organic Chemistry, Chiba University, Japan
1995 – 1999 B.Sc. Chemistry, (1st class honor), Chulalongkorn University, Thailand

Work Experiences
2015 – present Research Scientist I, Chulabhorn Research Institute, Thailand
2006 – 2015 Research Scientist, Chulabhorn Research Institute, Thailand

Awards
2015 Science and Technology Research Grant, Thailand Toray Science Foundation, Thailand
2014 ACP Lectureship to Taiwan, Asian CORE Program-NRCT
2000 – 2006 Monbukagakusho Scholarship, Japan
1998 Award for Excellence Academic Performance in Undergraduate Study, Dr. Tab Nilanidhi Foundation, Thailand
1997 Department of Chemistry Award of Excellence, Chulalongkorn University, Thailand
1995 – 1999 Development and Promotion of Science and Technology Talents Project (DPST), Thai government scholarship, Thailand

Publications
Selected Publications

1. Disadee, W.; Trisupphakant, K.; Ruchirawat, S. Synthesis of Novel Fluorescent Bicyclic Amidines and Evaluation of Their Photophysical Properties. Heterocycles 2022, 105, 417–437.
2. Disadee, W.; Ruchirawat, S. Oxazaborolidine-catalyzed Reductive Parallel Kinetic Resolution of Ketones from β-Nitro-Azabicycles for the Synthesis of Chiral Hypoestestatins 1, 2. Org. Biomol. Chem. 2021, 19, 8794–8805.
3. Disadee, W.; Lekky, A.; Ruchirawat, S. Metal-Free, One-Pot Cascade Annulation of 2-Pyrones in Water for the Synthesis of Peptidomimetics. J. Org. Chem. 2020, 85, 1802–1822.
4. Disadee, W.; Ruchirawat S. One-pot Cascade Synthesis of Azabicycles via the Nitro-Mannich Reaction and N-Alkylation. Org. Biomol. Chem. 2018, 16, 707–711.
5. Ruchirawat, S.; Disadee, W. A One-pot, Metal-free Approach to Bicyclic 2-Pyridones. Org. Chem. Front. 2017, 4, 2026–2030.
6. Disadee, W.; Mahidol, C.; Sahakitpichan, P.; Sitthimonchai, S.; Ruchirawat, S.; Kanchanapoom, T. Unprecedented Furan-2-carbonyl C-Glycosides and Phenolic Diglycosides from Scleropyrum pentandrum. Phytochemistry 2012, 74, 115–122.
7. Disadee, W; Ploypradith, P.; Aree, T.; Chaichit, N.; Ruchirawat, S. A Novel Approach for the Synthesis of Lophocladines A, B and C1-Analogues. Tetrahedron Lett. 2011, 52, 6142–6144.
8. Disadee, W.; Mahidol, C.; Sahakitpichan, P.; Sitthimonchai, S.; Ruchirawat, S.; Kanchanapoom, T. Flavonol 3-O-Robinobiosides and 3-O-(2”-O-α-Rhamnopyranosyl)-robinobiosides from Sesuvium portulacastrum. Tetrahedron 2011, 67, 4221–4226.
9. Disadee, W.; Ishikawa, T.; Kawahata, M.; Yamaguchi, K. Guanidinium Ylide Mediated Aziridination: Identification of a Spiro Imidazolidine-oxazolidine Intermediate. J. Org. Chem. 2006, 71, 6600–6603.
10. Disadee, W.; Ishikawa, T. Chirality Transfer from Guanidinium Ylides to 3-Alkenyl (or 3-Alkynyl)-aziridine-2-carboxylates and Application to the Syntheses of (2R,3S)-3-Hydroxyleucinate and D-Erythro-sphingosine. J. Org. Chem. 2005, 70, 9399–9406.
11. Disadee, W.; Ishikawa, T. Polymer-supported and Polymeric Chiral Guanidines: Preparation and Application to the Asymmetric Michael Reaction of Iminoacetate with Methyl Vinyl Ketone. Mol. Divers. 2005, 9, 321–331.
12. Shikii, K.; Seki, H.; Yamaguchi, K.; Disadee, W.; Watanabe, T.; Ishikawa, T. Facile Characterization of Polymer-supported Reagents using Cross Polarization Magic Angle Spinning Method in Solid State 13C-NMR. Chem. Pharma. Bull. 2004, 52, 864–865.
13. Disadee, W.; Watanabe, T.; Ishikawa, T. Polymer-supported DMI as a Potential Heterogeneous Dehydrating Agent: Application to Esterification and Amidation. Synlett 2003, 115–117.

Other Publications

1. Sahakitpichan, P.; Disadee,W.; Buntawong, R,; Chimnoi, N.; Ruchirawat, S.; Kanchanapoom, T. A Furan 2-Carbonyl C-Glucoside and an Alkyl Glucoside from the Parasitic Plant, Dendrophthoe pentandra. Phytochem. Lett. 2017, 21, 90–93.
2. Sahakitpichan, P.; Chadmuk, P.; Disadee, W.; Chimnoi, N.; Ruchirawat, S.; Kanchanapoom, T. New trans– and cis–p-Coumaroyl Flavonol Tetraglycosides from the Leaves of Mitragyna rotundifolia. Phytochem. Lett. 2014, 8, 65–68.
3. Phakeovilay, C.; Disadee, W.; Sahakitpichan, P.; Sitthimonchai, S.; Kittakoop, P.; Ruchirawat, S.; Kanchanapoom, T. Phenylethanoid and Flavone Glycosides from Ruellia tuberosa L. J. Nat. Med. 2013, 67, 228–233.
4. Sahakitpichan, P.; Mahidol, C.; Disadee, W.; Chimnoi, N.; Ruchirawat, S.; Kanchanapoom, T. Glucopyranosyloxybenzyl Derivatives of (R)-2-Benzylmalic Acid and (R)-Eucomic Acid, and an Aromatic Glucoside from the Pseudobulbs of Grammatophyllum speciosum. Tetrahedron 2013, 69, 1031–1037.
5. Worawittayanon, P.; Ruadreo, J.; Disadee, W.; Sahakitpichan, P.; Sitthimonchai, S.; Thasana, N.; Ruchirawat, S.; Kanchanapoom, T. Iridoid and Flavone Glycosides from Asystasia gangetica subsp. micrantha and A. salicifolia and Their Antioxidant Activities. Biochem. Syst. Ecol. 2012, 40, 38–42.
6. Sahakitpichan, P.; Mahidol, C.; Disadee, W.; Ruchirawat, S.; Kanchanapoom, T. Unusual Glycosides of Pyrrole Alkaloid and 4’-Hydroxyphenylethanamide from Leaves of Moringa oleifera. Phytochemistry 2011, 72, 791–795.
7. Sahakitpichan, P.; Disadee, W.; Ruchirawat, S.; Kanchanapoom, T. 3-Hydroxy-dihydrobenzofuran Glucosides from Gnaphalium polycaulon. Chem. Pharm. Bull. 2011, 59, 1160–1162.
8. Sahakitpichan, P.; Disadee, W.; Ruchirawat, S.; Kanchanapoom, T. L-(-)-(N–trans-Cinnamoyl)-Arginine, an Acylamino Acid from Glinus oppositifolius (L.) Aug. DC. Molecules 2010, 15, 6186–6192.
9. Manaka, T.; Nagayama, S.-I.; Disadee, W.; Yajima, N.; Kumamoto, T.; Watanabe, T.; Ishikawa, T.; Kawahata, M.; Yamaguchi, K. Ring-opening Reactions of 3-Aryl-1-benzylaziridine-2-carboxylates and Application to the Asymmetric Synthesis of an Amphetamine-type Compound. Helv. Chim. Acta 2007, 90, 128–142.