Staff – Natural Products

Mr. Nitirat Chimnoi

Category Staff - Natural Products
20 Feb 2023
2,154
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Name: Nitirat Chimnoi (Research Scientist I)

Office address: Room : R111/R303B
Laboratory of Natural Products
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 2553 8555 (ext. 3009)
E-mail: nitirat

Research Interests
Essential oils analysis
Utilization and extraction of bioactive compounds from Thai herbal plants
Chromatographic methods development and analysis
Mass spectrometry analysis of small molecules

Education
1997-2000 M.Sc. Analytical Chemistry, Chiangmai University, Chiangmai, Thailand.
1989-1993 B.A. Chemistry, Kasetsart University, Bangkok, Thailand.

Work Experiences
1993 – present Research Scientist, Chulabhorn Research Institute, Thailand

Awards
–

Publications

Selected Publications

  • Srinroch C.; Sahakitpichan P.; Chimnoi N.; Ruchirawat S.; Kanchanapoom T. Flavonol triglycosides from Magnolia utilis. Phytochemistry Letters, 2019, 29, 57-60.
  • Srinroch C.; Sahakitpichan P.; Techasakul S.; Chimnoi N,; Ruchirawat S.; Kanchanapoom T. 2-Aminobenzoyl and megastigmane glycosides from Wrightia antidysenterica. Phytochemistry Letters, 2019, 29, 61-64.
  • Srinroch C.; Sahakitpichan.; Chimnoi N.; Ruchirawat S.; Kanchanapoom T. Neolignan and monoterpene glycosides from Magnolia henryi. Phytochemistry Letters, 2019, 29, 94-97.
  • Khunnawutmanotham, N.; Laongthipparos, C.; Saparpakorn, P.; Chimnoi, N.; Techasakul, S. Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase. Beilstein J Org Chem. 14, 2018, 2545-52.
  • Chimnoi, N.; Reuk-ngam, N.; Chuysinuan, P.; Khlaychan, P.; Khunnawutmanotham, N.; Chokchaichamnankit, D.; Thamniyom, W.; Klayraung, S.; Mahidol, C.; Techasakul, S. Characterization of essential oil from Ocimum gratissimum leaves: Antibacterial and mode of action against selected gastroenteritis pathogens, Microbial Pathogenesis, 118, 2018, 290-300.
  • Sahakitpichan, P.; Chadmuk, P.; Chimnoi, N.; Namsa-aid, A.; Ruchirawat, S.; Kanchanapoom, T., 2-Carboxy-dihydrostilbene and flavan glycosides from Desmodium heterocarpon, Phytochemistry Letters, 19, 2017, 94-97.
  • Sahakitpichan, P.; Disadee, W.; Buntawong, R.; Chimnoi, N.; Ruchirawat, S.; Kanchanapoom, T. A furan-2-carbonyl C-glucoside and an alkyl glucoside from the parasitic plant, Dendrophthoe pentandra, Phytochemistry Letters, 21, 2017, 90-93.
  • Sahakitpichan, P.; Chimnoi, N.; Wongbundit, S.; Vorasingha, A.; Ruchirawat, S.; Kanchanapoom, T., Phenylethanoid glycosides from the leaves of Magnolia hodgsonii, Phytochemistry Letters, 21, 2017, 269-272.
  • Khunnawutmanotham, N.; Sahakitpichan, P.; Chimnoi, N.; Techasakul, S.; Efficient One-Pot Synthesis of Tetrahydronaphtho[2,1-f]isoquinolines by Using Domino Pictet–Spengler/Friedel–Crafts- Type Reactions, European Journal of Organic Chemistry, 43, 2017, 6434-40.
  • Chuysinuan, P.,Chimnoi, N. Pattani, L., Khlaychan, P., Nooeaid, P., and Techasakul, S.; Poly(lactic acid) (PLA) electrospun fibers containing rice extract: Release characteristics and their antioxidant activity (Conference Paper), Key Engineering Materials, 757, 2017, 83-87. (11th Pure and Applied Chemistry International Conference, PACCON 2017; Bangkok; Thailand; 2 February 2017 through 3 February 2017; Code 204019).
  • Boonsombat, J.; Mahidol, C.; Chawengrum, P.; Reuk-Ngam, N., Chimnoi, N.; Techasakul, S.; Ruchirawat, S.; Thongnest, S. Roscotanes and Roscoranes: Oxygenated Abietane and Pimarane diterpenoids from Kaempferia roscoeana. Phytochemistry, 2017, 143, 36–44.
  • Khunnawutmanotham, N.; Chimnoi, N.; Saparpakorn, P.; Techasakul, S. Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives. Bioorg. Chem., 2016, 65, 137-145.
  • Sahakitpichan, P.; Chimnoi, N.; Namsa-Aid, A.; Panyadee, A.; Ruchirawat, S.; Kanchanapoom, T. Colchicinoid glucosides from seedless pods of Thai origin Gloriosa superba, Phytochem. Lett., 2016, 16, 299-302.
  • Makarasen, A.; Reuk-ngam, N.; Chuysinuan, P.; Aonsri, C.; Isobe, M.; Techasakul, S., In vitro antimicrobial activity of cereulide and valinomycin compare with cyclic D, L-α-peptides and their enhanced effect. Int. J. Pharm. Biol. Sci., 2015, 6(1), 77-85.
  • Sahakitpichan, P.; Tanpatanan, W.; Chimnoi, N., Ruchirawat, S.; Kanchanapoom T. Glucosides of phenylpropanoic acid derivatives and coumarins from Micromelum minutum. Phytochem. Lett., 2015, 14, 12-16.
  • Khunnawutmanotham, N.; Sahakitpichan, P.; Chimnoi, N.; Techasakul, S., Divergent Total Syntheses to Azafluor­anthene and Dehydroaporphine Alkaloids. Eur. J. Org. Chem., 2015, 28, 6324-6332.
  • Thorroad, S.; Worawittayanont, P.; Khunnawutmanotham, N.; Chimnoi, N.; Jumruksa, A.; Ruchirawat, S.; Thasana, N. Three new Lycopodium alkaloids from Huperzia carinata and Huperzia squarrosa, Tetrahedron, 70(43), 2014, 8017-8022.
  • Reuk-Ngam, N., Chimnoi, N., Khunnawutmanotham, N. and Techasakul, S., Antimicrobial activity of coronarin D and its synergistic potential with antibiotics, Bio Med Res. Inter., 2014, 2014, Article ID 581985.
  • Sahakitpichan, P., Chadmuk, P., Disadee, W., Chimnoi, N., Ruchirawat, S. and Kanchanapoom, T., New trans- and cis-p-coumaroyl flavonol tetraglycosides from the leaves of Mitragyna rotundifolia, Phytochemistry Letters, 8(1), 2014, 65-68.
  • Kumarn, S., Chimnoi, N. and Ruchirawat, S., Synthesis of integerrimide A by an on-resin tandem Fmoc-deprotection-macrocyclisation approach Org. Biomol. Chem., 11(44), 2013, 7760-7767.
  • Chimnoi, N., Khunnawutmanotham, N., Feungfuloy, P., Chatrewongwan, K. and Techasakul, S., Facile isolation and purification of thailandine, a biologically active oxoaporphine alkaloid, from Stephania venosa leaves using ion-pair liquid-liquid extraction, Res. J. Med. Plant, 7(1), 2013, 68-76.
  • Sahakitpichan, P. Mahidol, C., Disadee, W., Chimnoi, N., Ruchirawat, S. and Kanchanapoom, T., Glucopyranosyloxybenzyl derivatives of (R)-2-benzylmalic acid and (R)-eucomic acid, and an aromatic glucoside from the pseudobulbs of Grammatophyllum speciosum, Tetrahedron, 69, 2013, 1031-1037.
  • Khunnawutmanotham, N., Chimnoi, N., Champathong, W., Lerdsirisuk, P., Khotmora, T. and Techasakul, S., Coronarin D conjugated to methylene homologues of chlorambucil: synthesis and evaluation of their cytotoxicity J. Chem. Res., 36, 2012, 374-378.
  • Kaomongkolgit, R., Jamdee, K., Wongnoi, S., Chimnoi, N. and Techasakul, S., Antifungal activity of coronarin D against Candida Albicans, Oral Surg. Oral Med. Oral Pathol., 114, 2012, 61-66.
  • Sutthivaiyakit, S. Seeka, C., Kritwinyu, T., Pisutchareonpong, S., and Chimnoi, N., 19-nor-11-Oxooleanan-12-ene and 18,19-seco-19-oxours- 11,13(18)-diene triterpenes from Diospyros decandra bark, J. Nat. Prod., 53, 2012, 1713-1716.
  • Chokchaichamnankit, D., Kongjinda, V., Khunnawutmanotham, N., Chimnoi, N., Pisutcharoenpong, S. and Techasakul, S., Prenylated flavonoids from the leaves of Derris malaccensis and their cytotoxicity, Nat. Prod. Comm., 6, 2011, 1103-1106.
  • Makarasen, A., Sirithana, W., Mogkhuntod, S., Khunnawutmanotham, N., Chimnoi, N. and Techasakul, S., Cytotoxic and Antimicrobial Activities of Aporphine Alkaloids Isolated from Stephania venosa (Blume) Spreng. Planta Med. 77, 2011, 1519-1524.
  • Duangthongyou, T., Makarasen, A., Techasakul, S., Chimnoi, N. and Siripaisarnpipat, S., (-)-Crebanine, Acta Cryst., 67, 2011, o402.
  • Chuysinuan, P., Chimnoi, N., Techasakul, S. and Supaphol, P., Gallic Acid-Loaded Electrospun Poly(L-Lactic Acid) Fiber Mats and their Release Characteristic, Macromolecular Chemistry and Physics, 210, 2009, 814-822.
  • Khunnawutmanotham, N., Chimnoi, N., Thitithanyanont, A., Saparpakorn, P., Choowongkomon, K., Pungpo, P., Hannongbua, S. and Techasakul, S., Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity, Beilstein J. Org. Chem., 22, 2009, 36.
  • Chimnoi, N., Sarasuk, C., Khunnawutmanotham, N., Intachote, P., Seangsai, S., Saimanee, B., Pisutjaroenpong, S. Mahidol, C. and Techasakul, S., Phytochemical reinvestigation of labdane-type diterpenes and their cytotoxicity from the rhizomes of Hedychium coronarium, Phytochemistry Letters, 2, 2009, 184-187.
  • Chimnoi, N., Pisutjaroenpong, S., Ngiwsara, L., Dechtrirut, D., Chokchaichamnankit, D., Khunnawutmanotham, N., Mahidol, C. and Techasakul, S., Labdane diterpenes from the rhizomes of Hedychium coronarium., Nat. Prod. Res., 22, 2008, 249-256.
  • Changtam, C., Sukcharoen, O., Yingyongnarongkul, B.E., Chimnoi, N. and Suksamrarn, A., Functional group-mediated biotransformation by Curvularia lunata NRRL 2178: synthesis of 3-dehydro-2-deoxy-ecdysteroids from the 3-hydroxy-2- mesyloxy analogues, Tetrahedron, 64 , 2008, 2626- 2633.
  • Khunnawutmanotham, N., Chimnoi, N., Saparpakorn, P., Pungpo, P.,
    Louisirirotchanakul, S., Hannongbua, S., and Techasakul, S., Novel 2- chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase, Molecule, 20, 2007, 218-230.
  • Suksamrarn, S., Komutiban, O., Ratananukul, P., Chimnoi, N., Lartpornmatulee, N. and Suksamrarn, A., Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana, Chemical & Pharmaceutical Bulletin, 54, 2006, 301-305.
  • Svasti, J., Srisomsap, C. , Subhasitanont, P., Keeratichamroen, S., Chokchaichamnankit, D. , Ngiwsara, L., Chimnoi, N., Pisutjaroenpong, S., Techasakul, S. and Chen, S.T., Proteomic profiling of Cholangiocarcinoma cell line treated with pomiferin from Derris malaccensis, Proteomics, 5, 2005, 4504-4509.
  • Yingyongnarongkul, B.E., Kumpun, S. and Chimnoi, N., C-25 epimeric 26- haloponasterone A:synthesis,absolute configuration and moulting activity, Steroids,70, 2005,636-644.
  • Phommart, S., Suthivaiyakit, P., Chimnoi, N., Ruchirawat, S. and Suthivaiyakit, S., Constituents of the leaves of Macaranga tanarius, J. Nat. Prod., 68, 2005, 927-930.
  • Mahidol, C., Chimnoi, N., Chokchaichamnankit, D. and Techasakul, S., Identification of volatile constituents in Artabotrys hexapetalus flowers using simple headspace solvent-trapping technique in combination with gas chromatography-mass spectrometry and retention indices, Acta Hortic., 2005, 43-50.
  • Homvisasevongsa, S., Chuaynugul, A., Chimnoi, N. and Suksamrarna, A., Stereoselective synthesis and moulting activity of 2,3-diepi-20-hydroxyecdysone and 2,3-diepi-5α-20-hydroxyecdysone, Tetrahedron, 60, 2004, 3433
  • Suksamrarn, S., Suwannapoch, N., Phakhodee, W., Thanuhiranlert, J., Ratananukul, P., Chimnoi, N. and Suksamrarn, A., Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana, Chem. Pharm. Bull., 51(7), 2003, 857-859.
  • Suksamrarn, A., Pattanaprateep, P., Tanachatchairatana, T., Haritakun, W., Yingyongnarongkul, B. and Chimnoi, N. , Chemical Modifications at the 22-hydroxyl group of Ecdysteroids : Alternative Structural Requirements for high Moulting Activity, Insect Biochem Mol Biol. , 32, 2002, 193-197.

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