Dr. Punyawee Dulyayangkul
Name: Dr. Punyawee Dulyayangkul
Office address: Research Laboratory of Biotechnology, Chulabhorn Research Institute,
54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand
Tel: +66 25530 8555 (ext. 3264)
Positions: Researcher, Research Laboratory of Biotechnology, Chulabhorn Research Institute
E-mail: [email protected]
Research Interests
- Antimicrobial resistance mechanisms
- Gram-negative bacterial pathogens
- Molecular biology
Education and Degrees
- Chulabhorn Graduate Institute (CGI), Thailand, 2013-2018
– Ph.D., Applied Biological Sciences (ABS): Environmental Health - Mahidol University International College (MUIC), Thailand, 2008-2011
– B.Sc., Biological Science
Postdoctoral Experience
- University of Bristol, UK, 2019-2022
– Postdoctoral Research Associate, School of Cellular and Molecular Medicine
Awards
- Royal Golden Jubilee (RGJ) Ph.D. Program Scholarship, 2015-2019
- His Majesty The King Honour Celebration Scholarships Project for the Scientists Development, 2013-2018
- First runner-up for the outstanding academic performance in the MUIC academic excellence scholarships, 2010
- First runner-up for the outstanding academic performance in the MUIC academic excellence scholarships, 2009
ORCID iD: https://orcid.org/0000-0003-2289-145X
Publications
Whangsuk W, Dulyayangkul P, Loprasert S, Dubbs JM, Vattanaviboon P, Mongkolsuk S. Re-sensitization of imipenem-resistant Pseudomonas aeruginosa and restoration of cephalosporins susceptibility in Enterobacteriaceae by recombinant Esterase B. Lett Appl Microbiol. 2024;77(12):ovae118. doi:10.1093/lambio/ovae118
Vanitshavit, V., Charoenlap, N., Sallabhan, R., Whangsuk, W., Bhinija, K., Dulyayangkul, P., Mongkolsuk, S., & Vattanavibooon, P. (2024). Acquired resistance of Stenotrophomonas maltophilia to antimicrobials induced by herbicide paraquat dichloride. PloS one, 19(8), e0309525. https://doi.org/10.1371/journal.pone.0309525
Dulyayangkul, P., Sealey, J. E., Lee, W. W. Y., Satapoomin, N., Reding, C., Heesom, K. J., Williams, P. B., & Avison, M. B. (2024). Improving nitrofurantoin resistance prediction in Escherichia coli from whole-genome sequence by integrating NfsA/B enzyme assays. Antimicrobial Agents and Chemotherapy, e0024224. doi: 10.1128/aac.00242-24
Dulyayangkul, P., Beavis, T., Lee, W. W. Y., Ardagh, R., Edwards, F., Hamilton, F., Head, I., Heesom, K. J., Mounsey, O., Murarik, M., Pinweha, P., Reding, C., Satapoomin, N., Shaw, J. M., Takebayashi, Y., Tooke, C. L., Spencer, J., Williams, P. B., & Avison, M. B. (2024). Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics. PLoS pathogens, 20(6), e1012235. doi: 10.1371/journal.ppat.1012235
Satapoomin, N., Dulyayangkul, P., Avison, M.B. (2022). Klebsiella pneumoniae Mutants Resistant to Ceftazidime-Avibactam Plus Aztreonam, Imipenem-Relebactam, Meropenem-Vaborbactam, and Cefepime-Taniborbactam. Antimicrobial Agents and Chemotherapy, 66(4), e0217921. doi: 10.1128/aac.02179-21.
Alzayn, M., Dulyayangkul, P., Satapoomin, N., Heesom, K. J., & Avison, M. B. (2021). OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in Escherichia coli in the Absence of Acquired β-Lactamases. Antimicrobial Agents and Chemotherapy, 65(11), e01004-21. doi: 10.1128/AAC.01004-21.
Gibbon, M. J., Couto, N., David, S., Barden, R., Standerwick, R., Jagadeesan, K., Birkwood, H., Dulyayangkul, P., Avison, M.B., Kannan, A., Kibbey, D., Craft, T., Habib, S., Thorpe, H.A., Corander, J., Kasprzyk-Hordern, B. & Feil, E. J. (2021). A high prevalence of bla OXA-48 in Klebsiella (Raoultella) ornithinolytica and related species in hospital wastewater in South West England. Microbial genomics, 7(3). doi: 10.1099/mgen.0.000509.
Dulyayangkul, P., Satapoomin, N., Avison, M. B., Charoenlap, N., Vattanaviboon, P., & Mongkolsuk, S. (2021). Over-expression of hypochlorite inducible major facilitator superfamily (MFS) pumps reduces antimicrobial drug susceptibility by increasing the production of MexXY mediated by ArmZ in Pseudomonas aeruginosa. Frontiers in Microbiology, 11, 3376. doi: 10.3389/fmicb.2020.592153.
Booton, R. D., Meeyai, A., Alhusein, N., Buller, H., Feil, E., Lambert, H., Mongkolsuk, S., Pitchforth, E., Reyher, K. K., Sakcamduang, W., Satayavivad, J., Singer, A. C., Sringernyuang, L., Thamlikitkul, V., Vass, L., OH-DART Study Group, Avison, M. B. & Turner, K. M. E. (2021). One Health drivers of antibacterial resistance: quantifying the relative impacts of human, animal and environmental use and transmission. One Health, 12, 100220. doi: 10.1016/j.onehlt.2021.100220.
Cheung, C. H. P., Dulyayangkul, P., Heesom, K. J., & Avison, M. B. (2020). Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. doi: 10.1128/AAC.00790-20.
Dulyayangkul, P., Douglas, E., Lastovka, F., & Avison, M. B. (2020). Resistance to Ceftazidime/Avibactam plus Meropenem/Vaborbactam When Both Are Used Together Is Achieved in Four Steps in Metallo-β-Lactamase-Negative Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. doi: 10.1128/AAC.00409-20.
Dulyayangkul, P., Ismah, W. A. K. W. N., Douglas, E. J., & Avison, M. B. (2020). Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy. doi: 10.1128/AAC.02208-19.
Dulyayangkul, P., Calvopiña, K., Heesom, K. J., & Avison, M. B. (2020). Novel mechanisms of efflux-mediated levofloxacin resistance and reduced amikacin susceptibility in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy, 65(1), e01284-20. doi: 10.1128/AAC.01284-20.
Calvopiña, K., Dulyayangkul, P., Heesom, K. J., & Avison, M. B. (2019). TonB‐dependent uptake of β‐lactam antibiotics in the opportunistic human pathogen Stenotrophomonas maltophilia. Molecular microbiology. doi: 10.1111/mmi.14434.
Calvopiña, K., Dulyayangkul, P., & Avison, M. B. (2019). Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activate Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia. Antimicrobial agents and chemotherapy. doi: 10.1128/AAC.01524-19.
Whittle, E. E., Legood, S. W., Alav, I., Dulyayangkul, P., Overton, T. W., & Blair, J. (2019). Flow Cytometric Analysis of Efflux by Dye Accumulation. Frontiers in microbiology, 10, 2319. doi: 10.3389/fmicb.2019.02319.
Vattanaviboon, P., Dulyayangkul, P., Mongkolsuk, S., & Charoenlap, N. (2018). Overexpression of Stenotrophomonas maltophilia major facilitator superfamily protein MfsA increases resistance to fluoroquinolone antibiotics. Journal of Antimicrobial Chemotherapy, 73(5), 1263-1266. doi: 10.1093/jac/dky024.
Dulyayangkul, P., Charoenlap, N., Srijaruskul, K., Mongkolsuk, S., & Vattanaviboon, P. (2016). Major facilitator superfamily MfsA contributes to multidrug resistance in emerging nosocomial pathogen Stenotrophomonas maltophilia. Journal of Antimicrobial Chemotherapy, 71(10), 2990-2991. doi: 10.1093/jac/dkw233.
Chancharoensin, S. Dulyayangkul, P., & Aung, L. (2013). Alkaline Mannanase Production from Bacillus subtilis Strain C3 in Complex Medium Containing Coconut Pulp. International Journal of Biotechnology & Biochemistry, 9(2), 211-219.
Chancharoensin, S., Srimahaeak, T., Dulyayangkul, P., & Luechai, S. (2012). Production of Reducing Sugar from Acid Pretreated Leaf Litter Using Crude Enzyme from Aspergillus niger Strain AK10. International Journal of Biotechnology & Biochemistry, 8(3), 279-287.
