Staff – Biochemistry

Dr. Voraratt Champattanachai

Category Staff - Biochemistry
29 Jan 2023
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Name: Voraratt Champattanachai

Office address: Research Laboratory of Biochemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Talat Bang Khen, Lak Si, Bangkok 10210, Thailand        
Tel: +662-5538555 ext. 3230, 3232
Fax: +662-5538560
Positions: Research Scientist II, Research Laboratory of Biochemistry, Chulabhorn Research Institute
E-mail: [email protected]
Website: –

Research Interests 
1. Cancer Biomarkers
2. Cancer immunotherapy
3. Human genetic diseases

Education and Degrees:

  • B.Sc. (Biology), Kasetsart University, Thailand
    M.S. (Biochemistry), Mahidol University, Thailand
    Ph.D. (Cell Biology), The University of Alabama at Birmingham, U.S.A

Academic Positions

  • Research Scientist II, Chulabhorn Research Institute, 2018-present
  • Research Scientist I, Chulabhorn Research Institute, 2014-2018
  • Research Scientist, Chulabhorn Research Institute, 1993-2014
  • Guest Lecturer, Chulabhorn Graduate Institute, 2002-present

Professional Societies (If any)

  • Member, The Science Society of Thailand under the Patronage of H.M. the King, 1998-present
  • Member, American Association of Anatomists, U.S.A., 2003-2007
  • Committee, Protein Society of Thailand, 2009-present
  • Steering committee, Asian Community of Glycoscience and Glycotechnology, (ACGG), Japan, 2011-2020
  • Member, Genetic Society of Thailand, Thailand, 2018-present
  • Editorial board of Molecular Medicine Reports (Spandidos Publications) and Oncology Reports (Spandidos Publications), 2019-present

Fellowships

  • Thai Government Scholarship (Ministry of Science and Technology, Thailand), 2002

International Awards & Honours

Local Awards & Honours

  • 1st Poster Presentation Award, 11th National Cancer Institute conference, 2012

Royal Decorations (If any)

ORCID iD (if available): http://orcid.org/0000-0002-4287-318x

Publications 
1. Effects of gentamicin inducing read through premature stop Codons: A study of alpha-L-iduronidase nonsense variants in COS-7 Cells. Ngiwsara L, Sawangareetrakula P, Wattanasirichaigoonb D, TimAroonb T, Dejkhamronc P, Champattanachaia V, Ketudat-Cairns J, Svasti J. Biochem. Biophys. Res. Commun.2022 Dec; 636: 147-154. doi: 10.1016/j.bbrc.2022.10-081.

2.Molecular characterization of Thai patients with phenylalanine hydroxylase deficiency and in vitro functional study of two novel PAH variants. Ngiwsara L, Vatanavicharn N, Sawangareetrakul P, Liammongkolkul S, Ratanarak P, Boonyawat B, Srisomsap C, Champattanachai V, Ketudat-Cairns J, Wasant P, Svasti J. Mol Biol Rep. 2021 Mar;48(3):2063-2070. doi: 10.1007/s11033-021-06163-w. Epub 2021 Mar 7.

3. Aberrant RL2 O-GlcNAc antibody reactivity against serum-IgA1 of patients with colorectal cancer. Verathamjamras C, Sriwitool TE, Netsirisawan P, Chaiyawat P, Chokchaichamnankit D, Prasongsook N, Srisomsap C, Svasti J, Champattanachai V. Glycoconj J. 2021 Feb;38(1):55-65. doi: 10.1007/s10719-021-09978-8. Epub 2021 Feb 20.

4. Aberrant proteins expressed in skin fibroblasts of Parkinson’s disease patients carrying heterozygous variants of glucocerebrosidase and parkin genes. Sawangareetrakul P, Ngiwsara L, Champattanachai V, Chokchaichamnankit D, Saharat K, Ketudat Cairns JR, Srisomsap C, Khwanraj K, Dharmasaroja P, Pulkes T, Svasti J. Biomed Rep. 2021 Apr;14(4):36. doi: 10.3892/br.2021.1412. Epub 2021 Feb 17.

5. Glycoproteomic Analysis Reveals Aberrant Expression of Complement C9 and Fibronectin in the Plasma of Patients with Colorectal Cancer. Chantaraamporn J, Champattanachai V, Khongmanee A, Verathamjamras C, Prasongsook N, Mingkwan K, Luevisadpibul V, Chutipongtanate S, Svasti J. Proteomes. 2020 Sep 22;8(3):26. doi: 10.3390/proteomes8030026.

6. Quantitative proteomic analysis of the association between decreasing O-GlcNAcylation and metastasis in MCF-7 breast cancer cells. Netsirisawan P, Chokchaichamnankit D, Saharat K, Srisomsap C, Svasti J, Champattanachai V. Int J Oncol. 2020 Jun;56(6):1387-1404. doi: 10.3892/ijo.2020.5022. Epub 2020 Mar 20.

7. Clinical course, mutations and its functional characteristics of infantile-onset Pompe disease in Thailand. Ngiwsara L, Wattanasirichaigoon D, Tim-Aroon T, Rojnueangnit K, Noojaroen S, Khongkraparn A, Sawangareetrakul P, Ketudat-Cairns JR, Charoenwattanasatien R, Champattanachai V, Kuptanon C, Pangkanon S, Svasti J. BMC Med Genet. 2019, 20(1):156. doi: 10.1186/s12881-019-0878-8.

8. Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma. Weeraphan C, Phongdara A, Chaiyawat P, Diskul-Na-Ayudthaya P, Chokchaichamnankit D, Verathamjamras C, Netsirisawan P, Yingchutrakul Y, Roytrakul S, Champattanachai V, Svasti J, Srisomsap C. Proteomics. 2019, 19(12):e1800159. doi: 10.1002/pmic.201800159. Epub 2019 May 27.

9. Decreasing O-GlcNAcylation affects the malignant transformation of MCF-7 cells via Hsp27 expression and its O-GlcNAc modification. Netsirisawan P, Chaiyawat P, Chokchaichamnankit D, Lirdprapamongkol K, Srisomsap C, Svasti J, Champattanachai V. Oncol Rep. 2018 Oct;40(4):2193-2205. doi: 10.3892/or.2018.6617. Epub 2018 Aug 1.

10. p.X654R IDUA variant among Thai individuals with intermediate mucopolysaccharidosis type I and its residual activity as demonstrated in COS-7 cells. Ngiwsara L, Ketudat-Cairns JR, Sawangareetrakul P, Charoenwattanasatien R, Champattanachai V, Kuptanon C, Pangkanon S, Tim-Aroon T, Wattanasirichaigoon D, Svasti J. Ann Hum Genet. 2018 May;82(3):150-157. doi: 10.1111/ahg.12236. Epub 2017 Dec 28.

11. New evidence of connections between increased O-GlcNAcylation and inflammasome in the oral mucosa of patients with oral lichen planus. Thi Do T, Phoomak C, Champattanachai V, Silsirivanit A, Chaiyarit P. Clin Exp Immunol. 2018 Apr;192(1):129-137. doi: 10.1111/cei.13091. Epub 2018 Jan 8.

12. Conference report: the 5th Asia Pacific Protein Association Conference joint meeting with the 12th International Symposium of the Protein Society of Thailand. Ketudat Cairns JR, Champattanachai V, Srisomsap C, Paricharttanakul NM, Verathamjamras C, Lirdprapamongkol K, Svasti J. Biophys Rev. 2017 Dec;9(6):857-860. doi: 10.1007/s12551-017-0318-y. Epub 2017 Sep 7. No abstract available.

13. Activation Status of Receptor Tyrosine Kinases as an Early Predictive Marker of Response to Chemotherapy in Osteosarcoma. Chaiyawat P, Klangjorhor J, Settakorn J, Champattanachai V, Phanphaisarn A, Teeyakasem P, Svasti J, Pruksakorn D. Transl Oncol. 2017 Oct;10(5):846-853. doi: 10.1016/j.tranon.2017.08.005. Epub 2017 Sep 4.

14. Molecular analysis of the novel IDS allele in a Thai family with mucopolysaccharidosis type II: The c.928C>T (p.Gln310*) transcript is sensitive to nonsense-mediated mRNA decay. Ngiwsara L, Rojnueangnit K, Wattanasirichaigoon D, Tim-Aroon T, Sawangareetrakul P, Champattanachai V, Ketudat-Cairns JR, Svasti J. Exp Ther Med. 2017 Jun;13(6):2989-2996. doi: 10.3892/etm.2017.4303. Epub 2017 Apr 5.

15. Secretomic profiling of cells from hollow fiber bioreactor reveals PSMA3 as a potential cholangiocarcinoma biomarker. Verathamjamras C, Weeraphan C, Chokchaichamnankit D, Watcharatanyatip K, Subhasitanont P, Diskul-Na-Ayudthaya P, Mingkwan K, Luevisadpaibul V, Chutipongtanate S, Champattanachai V, Svasti J, Srisomsap C. Int J Oncol. 2017 Jul;51(1):269-280. doi: 10.3892/ijo.2017.4024. Epub 2017 May 29.

16. Elevated O-GlcNAcylation of Extracellular Vesicle Proteins Derived from Metastatic Colorectal Cancer Cells. Chaiyawat P, Weeraphan C, Netsirisawan P, Chokchaichamnankit D, Srisomsap C, Svasti J, Champattanachai V. Cancer Genomics Proteomics. 2016 09-10;13(5):387-98.

17. Sawangareetrakul P, Ketudat Cairns JR, Vatanavicharn N, Liammongkolkul S, Wasant P, Svasti J, Champattanachai V. Analysis of Novel Mutations and Methylmalonyl-CoA Mutase Levels in Thai Patients with Isolated Methylmalonic Acidemia. Biochem Genet. 2015 Dec;53(11-12):310-8.

18. Chaiyawat P, Chokchaichamnankit D, Lirdprapamongkol K, Srisomsap C, Svasti J, Champattanachai V. Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells. Oncol Rep. 2015 Oct;34(4):1933-42. doi: 10.3892/or.2015.4178. Epub 2015 Aug 5.

19. Netsirisawan P, Chokchaichamnankit D, Srisomsap C, Svasti J, Champattanachai V. Proteomic Analysis Reveals Aberrant O-GlcNAcylation of Extracellular Proteins from Breast Cancer Cell Secretion. Cancer Genomics Proteomics. 2015 Jul-Aug;12(4):201-9.

20. Chaiyawat P, Netsirisawan P, Svasti J, Champattanachai V. Aberrant O-GlcNAcylated Proteins: New Perspectives in Breast and Colorectal Cancer. Front Endocrinol (Lausanne). 2014 Nov 11;5:193. doi: 10.3389/fendo.2014.00193. eCollection 2014. Review

21. Phueaouan T, Chaiyawat P, Netsirisawan P, Chokchaichamnankit D, Punyarit P, Srisomsap C, Svasti J, Champattanachai V. Aberrant O-GlcnAc-modified proteins expressed in primary colorectal cancer. Oncology Reports. 30: 2929-2936, 2013.

22. Champattanachai V, Netsirisawan P, Chaiyawat P, Phueaouan T, Charoenwattanasatien R, Chokchaichamnankit D, Punyarit P, Srisomsap C, Svasti J. Proteomic analysis and abrogated expression of O-GlcNAcylated proteins associated with primary breast cancer. Proteomics. 13(14):2088-99, 2013.

23. Charoenwattanasatien R, Cairns JR, Keeratichamroen S, Sawangareetrakul P, Tanpaiboon P, Wattanasirichaigoon D, Pangkanon S, Svasti J, Champattanachai V. Decreasing activity and altered protein processing of human iduronate-2-sulfatase mutations demonstrated by expression in COS7 Cells. Biochem Genet. 50: 990-7, 2012.

24. Vatanavicharn N, Champattanachai V, Liammongkokul S, Sawangareetrakul P, Keeratichamroem S, Cairns J, et al. Genetic analysis of mut, MMAA, and MMAB in Thai patients with isolated methylmalonic acidemia. Journal of Inherited Metabolic Disease [BC]. 2010; 33 (supplement: Suppl. (AUG 2010)): S42-S.

25. Vatanavicharn N, Champattanachai V, Liammongkolkul S, Sawangareetrakul P, Keeratichamroen S, Ketudat Cairns JR, Srisomsap C, Sathienkijkanchai A, Shotelersuk V, Kamolsilp M, Wattanasirichaigoon D, Svasti J, Wasant P. Clinical and molecular findings in Thai patients with isolated methylmalonic acidemia. Mol Genet Metab. 106(4): 424-9, 2012.

26. Vatanavicharn N, Champattanachai V, Liammongkokul S, Sawangareetrakul P, Keeratichamroem S, Cairns J, et al. Genetic analysis of mut, MMAA, and MMAB in Thai patients with isolated methylmalonic acidemia. Journal of Inherited Metabolic Disease [BC]. 33 (supplement: Suppl. (AUG 2010)): S42-S, 2010.

27. Zou L, Yang S, Champattanachai V, Hu S, Chaudry IH, Marchase RB, Chatham JC. Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-(kappa) B signaling. Am J Physiol Heart Circ Physiol. 296(2): H515-23, 2009.

28. Champattanachai V, Marchase RB, and Chatham JC. Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and mitochondrial Bcl-2. Am J Physiol Cell Physiol, 294(6): C1509-20, 2008.

29. Keeratichamroen S, Cairns JR, Sawangareetrakul P, Liammongkolkul S, Champattanachai V, Srisomsap C, Kamolsilp M, Wasant P, and Svasti J. Novel mutations found in two genes of thai patients with isolated methylmalonic acidemia. Biochem Genet 45: 421-430, 2007.

30. Champattanachai V, Marchase RB, and Chatham JC. Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc. Am J Physiol Cell Physiol 292: C178-187, 2007.

31. Nagy T, Champattanachai V, Marchase RB, and Chatham JC. Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine. Am J Physiol Cell Physiol 290: C57-65, 2006.

32. Ketudat Cairns JR, Keeratichamroen S, Sukcharoen S, Champattanachai V, Ngiwsara L, Lirdprapamongkol K, Liammongkolkul S, Srisomsap C, Surarit R, Wasant P, and Svasti J. The molecular basis of mucopolysaccharidosis type I in two Thai patients. Southeast Asian J Trop Med Public Health 36: 1308-1312, 2005.

33. Ketudat Cairns JR, Champattanachai V, Srisomsap C, Wittman-Liebold B, Thiede B, and Svasti J. Sequence and expression of Thai Rosewood beta-glucosidase/beta-fucosidase, a family 1 glycosyl hydrolase glycoprotein. J Biochem (Tokyo) 128: 999-1008, 2000.

34. Srisomsap C, Svasti J, Surarit R, Champattanachai V, Sawangareetrakul P, Boonpuan K, Subhasitanont P, and Chokchaichamnankit D. Isolation and characterization of an enzyme with beta-glucosidase and beta-fucosidase activities from Dalbergia cochinchinensis Pierre. J Biochem (Tokyo) Mar:119(3): 585-590, 1996. doi: 10.1093/oxfordjournals.jbchem.a021282.

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